Q4R7T5

PR
Gene name
CDKL2
Protein name
Cyclin-dependent kinase-like 2
Names
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

270-442 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

143-166 (Activation loop from InterPro)

Target domain

4-287 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q4R7T5

Entry ID Method Resolution Chain Position Source
AF-Q4R7T5-F1 Predicted AlphaFoldDB

No variants for Q4R7T5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4R7T5

No associated diseases with Q4R7T5

3 regional properties for Q4R7T5

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 287 IPR000719
active_site Serine/threonine-protein kinase, active site 122 - 134 IPR008271
binding_site Protein kinase, ATP binding site 10 - 34 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKYENLGLV GEGSYGMVVK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH
70 80 90 100 110 120
ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY QVVQKYLFQI INGIGFCHSH
130 140 150 160 170 180
NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG
190 200 210 220 230 240
KAVDVWAIGC LVTEMFMGEP LFPGDSDIDQ LYHIMMCLGN LIPRHQELFY KNPVFAGVRL
250 260 270 280 290 300
PEIKEREPLE RRYPKLSEVV IDLAKKCLHI DPDKRPFCSE LLHHDFFQMD GFAERFSQEL
310 320 330 340 350 360
QLKVQKDARN ISLSKKSQNR KKEKEKDDSL GEERKTLVVQ DTNADPKIKD CKLFKIKGSK
370 380 390 400 410 420
IDGEKAEKGN RASNASCLHD SRTSHIKIVP STSLKDCSNV SVDHTRNPGV AIPPLMHNLS
430 440 450 460 470 480
AVAPGINSGM GTATLPIQSY RVDEKTKKCS IPFVKPNRHS PSGIYNINVT TLVSSEKSLF
490 500 510 520 530 540
RASKKRREYS RTDVHLPELN YNHLPELRAL EGTARNSRLT KKESKILSES RIPSLAAIDL
550 560
HTPSITLHQV SGPPLSDDSG ADLPQMEHQH