Q4R5V2

PR
Gene name
EMC7 (QtsA-20627)
Protein name
ER membrane protein complex subunit 7
Names
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

157-242 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4R5V2

Entry ID Method Resolution Chain Position Source
AF-Q4R5V2-F1 Predicted AlphaFoldDB

No variants for Q4R5V2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4R5V2

No associated diseases with Q4R5V2

1 regional properties for Q4R5V2

Type Name Position InterPro Accession
domain ER membrane protein complex subunit 7, beta-sandwich domain 57 - 168 IPR019008

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
EMC complex A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
carbohydrate binding Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.

2 GO annotations of biological process

Name Definition
protein insertion into ER membrane by stop-transfer membrane-anchor sequence A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix.
tail-anchored membrane protein insertion into ER membrane A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAALWGFFP VLLLLLLSGD VQSSEVPGAA AEGSGGSGVG IGDRFKIEGR AVVPGVKPQD
70 80 90 100 110 120
WISAARVLVD GEEHVGFLKT DGSFVVHDIP SGSYVVEVVS PAYRFDPVRV DITSKGKMRA
130 140 150 160 170 180
RYVNHIKTSE VVRLPYPLQM KSSGPPSYFI KRESWGWTDF LMNPMVMMMV LPLLIFVLLP
190 200 210 220 230 240
KVVNTSDPDM RREMEQSMNM LNSNHELPDV SEFMTRLFSS KSSGKSSSGS SKTGKSGAGK
RR