Q4R5Q4

PR
Gene name
ECSIT
Protein name
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Names
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
mcf:107126402
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

17-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4R5Q4

Entry ID Method Resolution Chain Position Source
AF-Q4R5Q4-F1 Predicted AlphaFoldDB

No variants for Q4R5Q4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4R5Q4

No associated diseases with Q4R5Q4

10 regional properties for Q4R5Q4

Type Name Position InterPro Accession
repeat WD40 repeat 46 - 86 IPR001680-1
repeat WD40 repeat 88 - 127 IPR001680-2
repeat WD40 repeat 132 - 171 IPR001680-3
repeat WD40 repeat 185 - 225 IPR001680-4
repeat WD40 repeat 228 - 275 IPR001680-5
repeat WD40 repeat 386 - 465 IPR001680-6
repeat WD40 repeat 491 - 530 IPR001680-7
domain Lethal giant larvae homologue 2 277 - 385 IPR013577
domain Lethal giant larvae (Lgl)-like, C-terminal domain 907 - 1027 IPR013905
domain v-SNARE, coiled-coil homology domain 1087 - 1147 IPR042855

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
regulation of oxidoreductase activity Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
regulation of protein complex stability Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSWVQATLLA RGLCRAWGGI CRAALPGTSI SQVPRQLPRG LHCSAAPHSS EQSLVSSPPE
70 80 90 100 110 120
PRQRPTKALV PYEDLFGQAP SGERDKASFL QAVQKFGEHS VRKRGHIDFI YLALRKMREY
130 140 150 160 170 180
GVERDLAVYN QLLDIFPKEV FRPRNVIQRI FVHYPRQQEC GIAVLEQMES HGVMPNKETE
190 200 210 220 230 240
FLLIQIFGRK SYPMLKLLRL KMWFPRFMNI NPFPVPRDLS QDPVELATFG LRHMEPDLSA
250 260 270 280 290 300
RVTIYQVPLP KDSTGAADPP QPHIVGIQSP DQQAALARHN PARPIFVEGP FSLWLRNKCV
310 320 330 340 350 360
YYHILRADLL PPEEREVEET PEEWNLYYPM QLDLEYSRSG WDDYEFDINE VEEGPVFAMC
370 380 390 400 410 420
MAGAHDQATL AKWIQGLQET NPTLAQIPVV FRLTRATGEL HTSSAGLEEP PPPEDHEEDD
SRQRQQQGQS