Q4R4T6

PR
Gene name
DDX28 (QccE-21131)
Protein name
Probable ATP-dependent RNA helicase DDX28
Names
Mitochondrial DEAD box protein 28
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-150 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4R4T6

Entry ID Method Resolution Chain Position Source
AF-Q4R4T6-F1 Predicted AlphaFoldDB

No variants for Q4R4T6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4R4T6

No associated diseases with Q4R4T6

4 regional properties for Q4R4T6

Type Name Position InterPro Accession
domain Helicase, C-terminal 377 - 536 IPR001650
domain DEAD/DEAH box helicase domain 152 - 337 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 147 - 368 IPR014001
domain RNA helicase, DEAD-box type, Q motif 126 - 156 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
  • Mitochondrion
  • Mitochondrion matrix, mitochondrion nucleoid
  • Mitosome matrix
  • Transported between these two compartments
  • Nuclear localization depends on active RNA polymerase II transcription
  • Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
mitochondrial nucleoid The region of a mitochondrion to which the DNA is confined.
mitosome A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria. The mitosome has been detected only in anaerobic or microaerophilic organisms that do not have mitochondria, such as Entamoeba histolytica, Giardia intestinalis and several species of Microsporidia. These organisms are not capable of gaining energy from oxidative phosphorylation, which is normally performed by mitochondria.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein granule A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.
rRNA binding Binding to a ribosomal RNA.

1 GO annotations of biological process

Name Definition
mitochondrial large ribosomal subunit assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALSRPVRLF SLVARLILAP RRGLTVRSPD EPLPVVRIPV ALQRQLEQRQ SRQRNLPRPV
70 80 90 100 110 120
LARPGRLLVS ARRPEFNQPA RLTLGRWESA PLASQGWKSR RARRDHFSIE RAQQEAPAVQ
130 140 150 160 170 180
KLSSEGNFAD LGLEPRVLHA LQEVAPEVVQ PTTVQSNTIP QLLRGRHVLC AAETGSGKTL
190 200 210 220 230 240
SYLLPLFQRL MVQPSLDSLR IPAPRGLVLV PSRELAQQVQ AVAQPLGRSL GLLVRDLEGG
250 260 270 280 290 300
HGMCRIRMQL ARQPSADVLV ATPGALWKAL KSRLISLEQL SFLVLDEADT LLDESFLELV
310 320 330 340 350 360
DCILEKSHIA DGPADLEDRF NPKAQLVLVG ATFPEGVGQL LDKVASPDAV TTITSSNLHC
370 380 390 400 410 420
IMPHVKQTFL RLKGADKVAE LVHILKHHNR AERTGPSGTV LVFCNSSSTV NWLGYILDDH
430 440 450 460 470 480
KIQHLRLQGQ MPALMRAGIF QSFQKSSRDI LLCTDIASRG LDSTGVELVV NYDFPPTLQD
490 500 510 520 530 540
YIHRAGRVGR VGSEVPGTVI SFVTHPWDVS LVQKIELAAR RRRSLPGLVS SVKEPLPQQP
DFDKSD