Q4R4I8

PR
Gene name
COPB2 (QtrA-12583)
Protein name
Coatomer subunit beta'
Names
Beta'-coat protein, Beta'-COP
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

794-906 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4R4I8

Entry ID Method Resolution Chain Position Source
AF-Q4R4I8-F1 Predicted AlphaFoldDB

No variants for Q4R4I8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4R4I8

No associated diseases with Q4R4I8

7 regional properties for Q4R4I8

Type Name Position InterPro Accession
repeat WD40 repeat 4 - 85 IPR001680-1
repeat WD40 repeat 88 - 127 IPR001680-2
repeat WD40 repeat 131 - 266 IPR001680-3
domain Coatomer, WD associated region 319 - 762 IPR006692
repeat G-protein beta WD-40 repeat 158 - 172 IPR020472-1
repeat G-protein beta WD-40 repeat 202 - 216 IPR020472-2
repeat G-protein beta WD-40 repeat 244 - 258 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side
  • The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it
  • Shows only a slight preference for the cis-Golgi apparatus, compared with the trans-Golgi
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
COPI-coated vesicle membrane The lipid bilayer surrounding a COPI-coated vesicle.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.

1 GO annotations of molecular function

Name Definition
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

2 GO annotations of biological process

Name Definition
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPLRLDIKRK LTARSDRVKS VDLHPTEPWM LASLYNGSVC VWNHETQTLV KTFEVCDLPV
70 80 90 100 110 120
RAAKFVARKN WVVTGADDMQ IRVFNYNTLE RVHMFEAHSD YIRCIAVHPT QPFILTSSDD
130 140 150 160 170 180
MLIKLWDWDK KWSCSQVFEG HTHYVMQIVI NPKDNNQFAS ASLDRTIKVW QLGSSSPNFT
190 200 210 220 230 240
LEGHEKGVNC IDYYSGGDKP YLISGADDRL VKIWDYQNKT CVQTLEGHAQ NVSCASFHPE
250 260 270 280 290 300
LPIIITGSED GTVRIWHSST YRLESTLNYG MERVWCVASL RGSNNVALGC DEGSIIVKLG
310 320 330 340 350 360
REEPAMSMDA NGKIIWAKHS EVQQANLKAM GNAEIKDGER LPLAVKDMGS CEIYPQTIQH
370 380 390 400 410 420
NPNGRFVVVC GDGEYIIYTA MALRNKSFGS AQEFAWAHDS SEYAIRESNS VVKIFKNFKE
430 440 450 460 470 480
KKSFKPDFGA ESIYGGFLLG VRSVNGLAFY DWDNTELIRR IEIQPKHIFW SGSGELVCIA
490 500 510 520 530 540
TEESFFILKY LSEKVLAAQE THEGVTEDGI EDAFEVLGEI QEIVKTGLWV GDCFIYTSSV
550 560 570 580 590 600
NRLNYYVGGE IVTIAHLDRT MYLLGYIPKD NRLYLGDKEL NIVSYSLLVS VLEYQTAVMR
610 620 630 640 650 660
RDFSMADKVL PTIPKEQRTR VAHFLEKQGF KQQALTVSTD PEHRFELALQ LGELKIAYQL
670 680 690 700 710 720
AVEAESEQKW KQLAELAISK CQFGLAQECL HHAQDYGGLL LLATASGNAN MVNKLAEGAE
730 740 750 760 770 780
RDGKNNVAFM SYFLQGKVDA CLELLIRTGR LPEAAFLART YLPSQVSRVV KLWRENLSKV
790 800 810 820 830 840
NQKAAESLAD PTEYENLFPG LKEAFVVEEW VKETHADLWP AKQHPLVTPN EERNVMEEAK
850 860 870 880 890 900
GFQPSRSTAQ QELDGKPASP TPVIVASHTA NKEEKSLLEL EVDLDNLELE DIDTTDINLD
EDILDD