Q4R445

PR
Gene name
SLC26A8
Protein name
Testis anion transporter 1
Names
Anion exchange transporter, Solute carrier family 26 member 8
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

554-655 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4R445

Entry ID Method Resolution Chain Position Source
AF-Q4R445-F1 Predicted AlphaFoldDB

No variants for Q4R445

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4R445

No associated diseases with Q4R445

2 regional properties for Q4R445

Type Name Position InterPro Accession
domain STAS domain 471 - 692 IPR002645
domain SLC26A/SulP transporter domain 20 - 421 IPR011547

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
  • Located at both the annulus and the equatorial segment of the human sperm head
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
anion transmembrane transporter activity Enables the transfer of a negatively charged ion from one side of a membrane to the other.

3 GO annotations of biological process

Name Definition
flagellated sperm motility The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
sperm capacitation A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLTIFPFLEW MCMYRLKDWL LGDLLAGISV GLVQVPQGLT LSLLARQLIP PLNIAYAAFC
70 80 90 100 110 120
SSVIYVIFGS CHQMSIGSFF LVSALLINVL KISPLNNGHL VMGSFLKDEF SAPSYLMGYN
130 140 150 160 170 180
KSLSVVATTT FLTGIIQLIM GVLGLGFIAT YLPESAMSAY LAAVALHIML SQLTCIFGIM
190 200 210 220 230 240
ISFHAGPISF FYDIINYCVA LPKANSTSIL LFLTVVVALR INKCIRISFN QYPIEFPMEL
250 260 270 280 290 300
FLIIGFTVIG NKITMATETS QTLIDMIPYS FLFPVTPDFS VLPKIILQAI SLSLVSSFLL
310 320 330 340 350 360
VFLGKKIASL HNYSVNSNQD LIAIGLCNVV SSFFRSCVFT GAVARTIIQD KSGGRQQFAS
370 380 390 400 410 420
LVGAGVMLLL MVKMGHFFYA LPNAVLAGII LSNVVPYLET ISNLPSLWRQ DQYDCALWMM
430 440 450 460 470 480
TFSSSIFLGL DIGLIISVVS AFFITSVRSH RAKILLLGQI PNTNIYRSVN DYREIITIPG
490 500 510 520 530 540
VKIFQCCSSI TFVNVYYLKH KLLKEVGMVR VPLKEEEIFS LFNSSDTSLQ GEKICRCFCN
550 560 570 580 590 600
CDDLEPLPRI LYTERFENKL DPDASSVNLI HCSHFESVNT SQTASEDQVP YTVSSMSQKN
610 620 630 640 650 660
QGQQYEEVEK VWLPNNSSRN SSPGLPDVAE SQGRRSLIPY SDASLLPSVH TIILDFSMVH
670 680 690 700 710 720
YVDSQGLVVL RQICNAFRNA NILILIAGCH SSLFCTGITL PDHITKCQQL SLNSLSRLPS
FHLQHIF