Q4PIC4
Gene name |
SPT5 (UMAG_10033) |
Protein name |
Transcription elongation factor SPT5 |
Names |
Chromatin elongation factor SPT5 |
Species |
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) |
KEGG Pathway |
uma:UMAG_10033 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4PIC4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4PIC4-F1 | Predicted | AlphaFoldDB |
No variants for Q4PIC4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4PIC4 | |||||
No associated diseases with Q4PIC4
14 regional properties for Q4PIC4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | NGN domain | 203 - 290 | IPR005100 |
| domain | KOW | 298 - 325 | IPR005824-1 |
| domain | KOW | 464 - 491 | IPR005824-2 |
| domain | KOW | 517 - 545 | IPR005824-3 |
| domain | KOW | 639 - 667 | IPR005824-4 |
| domain | KOW | 740 - 767 | IPR005824-5 |
| domain | NusG-like, N-terminal | 201 - 293 | IPR006645 |
| domain | Spt5 transcription elongation factor, N-terminal | 102 - 197 | IPR022581 |
| domain | NGN domain, eukaryotic | 203 - 291 | IPR039385 |
| domain | Spt5, KOW domain repeat 1 | 302 - 339 | IPR041973 |
| domain | Spt5, KOW domain repeat 2 | 466 - 516 | IPR041975 |
| domain | Spt5, KOW domain repeat 3 | 517 - 567 | IPR041976 |
| domain | Spt5, KOW domain repeat 4 | 643 - 687 | IPR041977 |
| domain | Spt5, KOW domain repeat 5 | 738 - 789 | IPR041978 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| DSIF complex | A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| transcription elongation factor activity | A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| regulation of DNA-templated transcription elongation | Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| transcription elongation by RNA polymerase II promoter | The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDDNIEIKRE | DQTSHALVPD | KDRKSRIQHG | GKRPIDPFAA | EDDDEEEERG | DAVDEQDQDD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DEDDDEDDDD | DDDDEDDDED | DEEDDTARGQ | RRRAKKQRRN | RFLDVEAEVD | DDEEDLDEEE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EELAREDGFI | EEDIPDDTED | VQRRAAADNQ | RLDRFRRQEE | DTNAEALAEE | LRQRYGRSAR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YAAQSDYAEV | PQRLLMPSVE | DPSLWGVPCK | PGRERDIVMT | LVRKAMAENF | TSSPMRIISA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FCRDSIPGRV | YVEARRADDV | VKACNGLAGA | YARQTTSLHL | IPISEMADLL | KLQKVQNEIQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VGGWVRIKRG | KYAGDLAQVL | DVSENGEEVG | LKMIPRIDLN | PKDSGLYTDS | LGRKRKKGAG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSATTVAFRP | PQRFFNPEEV | QKAYPRDTPT | KRGSQWVFQN | DSYRDGYLEK | DVRVTGIITE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NVNPTLDEIT | KFAGESSIED | GINKLGAVDL | SLIADASKKA | TEALIQPKDQ | VEIFEGEQAG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VYGTVKAINN | EVITIQLEHE | DLMDQIVEVP | ARSVRKRFKP | GDHIKVMSGK | HADETGLVVK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VEDNVTTFLS | DLSMQEVSVF | SKDIRQAAEV | GSGVNVISGY | ELHNLVQLDA | QTVGIIFNIE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RESFKVLDQT | GQVVTVKPHQ | ISTKKDTSRA | FALDHDGNEI | RAGDMVKEVA | GPFSRLRQGQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VLHIYQSMVV | FLHNREYTEN | GGVFIARARS | LEPLAPKSVS | TKTKKDGGDL | SKMNPALSNL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SGGGANDVRV | EGVRRFGGRD | MHKGKNVAII | KGPYKTYRGR | ITETTGNMAR | IELTSVSKPI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TVSLDWLVEK | DPITGRSTKL | NAGGFGGPSR | GGHSGTGSRM | GGASSNPYSS | GSTSMGAGGR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| YNPYGGSQPA | AAVGSYGGSS | GTGAGGYGGY | SQPVATSAAG | ASGYGGTGGI | GARTPAYNPY |
| 910 | 920 | 930 | 940 | 950 | |
| AGDGGKTPAY | NPYGDGGKTP | AYNPLGDGGK | TPAYNAAADG | GRTPGYNPYA | GDGW |