Q4P9P9

PR
Gene name
PAC1
Protein name
Nuclear distribution protein PAC1
Names
Lissencephaly-1 homolog, LIS-1, nudF homolog
Species
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
KEGG Pathway
uma:UMAG_03164
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4P9P9

Entry ID Method Resolution Chain Position Source
AF-Q4P9P9-F1 Predicted AlphaFoldDB

No variants for Q4P9P9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4P9P9

No associated diseases with Q4P9P9

10 regional properties for Q4P9P9

Type Name Position InterPro Accession
repeat WD40 repeat 111 - 195 IPR001680-1
repeat WD40 repeat 196 - 452 IPR001680-2
domain LIS1 homology motif 19 - 51 IPR006594
conserved_site WD40 repeat, conserved site 179 - 193 IPR019775-1
conserved_site WD40 repeat, conserved site 222 - 236 IPR019775-2
conserved_site WD40 repeat, conserved site 264 - 278 IPR019775-3
conserved_site WD40 repeat, conserved site 373 - 387 IPR019775-4
repeat G-protein beta WD-40 repeat 222 - 236 IPR020472-1
repeat G-protein beta WD-40 repeat 331 - 345 IPR020472-2
repeat G-protein beta WD-40 repeat 373 - 387 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cytoskeleton, spindle pole
  • Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasmic microtubule Any microtubule in the cytoplasm of a cell.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
microtubule associated complex Any multimeric complex connected to a microtubule.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

2 GO annotations of molecular function

Name Definition
dynein complex binding Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.
microtubule plus-end binding Binding to the plus end of a microtubule.

6 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
establishment of mitotic spindle orientation A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
microtubule organizing center organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.
microtubule sliding The movement of one microtubule along another microtubule.
nuclear migration The directed movement of the nucleus to a specific location within a cell.
vesicle transport along microtubule The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGFNGTSTS SNSILSERQK DELHKSILDY FKTNNLHESF ATLMREANQE GFVPDPRAKY
70 80 90 100 110 120
AGLLEKKWTS VIRLQKKIME MESRISQLQE ELSAAPSAKR SASLNDWLPA ASSARHTMQG
130 140 150 160 170 180
HRLPVTKVSF HPVFSQIASA SEDTTVKLWD WETGDFERTL KGHTKAVQDV DFDSKGNYVL
190 200 210 220 230 240
SCSSDLSIKV WDANNDYKNI KTLQGHDHSV SSVRFLPGDD YIVSASRDKT IKIWEFSTGF
250 260 270 280 290 300
CTKTLQGHAE WVRSAIPSDD AKWLVSCSTD QTARVWDVSS GETKVELRGH EHVVEVAIFA
310 320 330 340 350 360
PVASYAAIRQ LASLDPNASK DASASMAGQF VATGSRDKTI RIWDSISGQC LKTLTGHDNW
370 380 390 400 410 420
VRGLAFSPNG KSLLSVSDDK TMRLWDLQSG RCTRTIEAHQ HFATGIAWGK AKIEAPIPPA
430 440 450
QDGEEAGRKQ PEARTVNVVA TSSVDLTIKI WTP