Q4L7M3

PR
Gene name
purB (SH1043)
Protein name
Adenylosuccinate lyase
Names
ASL, Adenylosuccinase, ASase
Species
Staphylococcus haemolyticus (strain JCSC1435)
KEGG Pathway
sha:SH1043
EC number
4.3.2.2: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

220-298 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4L7M3

Entry ID Method Resolution Chain Position Source
AF-Q4L7M3-F1 Predicted AlphaFoldDB

No variants for Q4L7M3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4L7M3

No associated diseases with Q4L7M3

3 regional properties for Q4L7M3

Type Name Position InterPro Accession
domain Adenylosuccinate lyase C-terminal 349 - 429 IPR019468
conserved_site Fumarate lyase, conserved site 261 - 270 IPR020557
domain Fumarate lyase, N-terminal 7 - 286 IPR022761

Functions

Description
EC Number 4.3.2.2 Lyases acting on amides, amidines, etc
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.

2 GO annotations of biological process

Name Definition
'de novo' AMP biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIDRYSREEM ANIWTDQNRY EAWLEVEILA CEAWSELGHI PKEDVKKIRQ NAKVDVKRAQ
70 80 90 100 110 120
EIEQETRHDV VAFTRQVSET LGDERKWVHY GLTSTDVVDT ALSYVIKQAN EIIEKDIERF
130 140 150 160 170 180
IKVLEEKAKN YKYTLMMGRT HGVHAEPTTF GVKMALWYTE MKRNLKRFKE VRKEIEVGKM
190 200 210 220 230 240
SGAVGTFANI PPEIEQYVCD HLGIDTASVS TQTLQRDRHA YYIATLALVA TSLEKFAVEI
250 260 270 280 290 300
RNLQKTETRE VEEAFAKGQK GSSAMPHKRN PIGSENITGI SRVIRGYITT AYENVPLWHE
310 320 330 340 350 360
RDISHSSAER IMLPDVTIAL DYALNRFTNI VDRLTVFEDN MRNNIDKTFG LIFSQRVLLA
370 380 390 400 410 420
LINKGMVREE AYDRVQPKAM ESWETKTPFR QLIEKDESIT NVLSKEELDE CFNPEHHLNQ
430
VDTIFKRAGL E