Q4L6W5

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Staphylococcus haemolyticus (strain JCSC1435)
KEGG Pathway
sha:SH1301
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

139-260 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4L6W5

Entry ID Method Resolution Chain Position Source
AF-Q4L6W5-F1 Predicted AlphaFoldDB

No variants for Q4L6W5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4L6W5

No associated diseases with Q4L6W5

4 regional properties for Q4L6W5

Type Name Position InterPro Accession
domain DHHA1 domain 744 - 878 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 662 - 705 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 564 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 718 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKNLKASEIR QKYIDFFVEK GHMVEPSAPL VPIDDDSLLW INSGVATLKK YFDGRETPRK
70 80 90 100 110 120
PRIVNSQKAI RTNDIENVGF TARHHTFFEM LGNFSIGDYF KKEAIHFAWE FLTSENWMGM
130 140 150 160 170 180
EPEKLYVTIH PEDSEAYRIW NDEIGLEESR IIRIEGNFWD IGEGPSGPNT EIFYDRGDEY
190 200 210 220 230 240
GQDDPSEEMY PGGENERYLE VWNLVFSEFN HNKDNTYTPL PNKNIDTGMG LERMASVSQN
250 260 270 280 290 300
VRTNYETDLF MPIINEVEKV ADKKYLVNNE HDIAFKVIAD HIRTIAFAIA DGALPANEGR
310 320 330 340 350 360
GYVLRRLLRR AVRFSQTLDI NEPFMYKLVD IVAEIMEPYY PNVKEKADFI KRVIKSEEER
370 380 390 400 410 420
FHETLQEGLA ILNNLLAKAK SSNNEINGSD AFKLYDTYGF PIELTEELAS QENISVDMAT
430 440 450 460 470 480
FEKEMDQQRT RAREARQSSQ SMQIQSEVLK NITTESKFVG YETTDYQTTL TDLIYNGEKV
490 500 510 520 530 540
ESAEPGETVY FILKETPFYA VSGGQVADKG TVGNENFEIE VTEVTKAPNG QNLHQGVIQF
550 560 570 580 590 600
GQVTINSDVD ASVNRDERKD IQKNHSATHL LHAALKEVLG EHVNQAGSLV ESERLRFDFS
610 620 630 640 650 660
HFGPMTQDEI DQVERRVNEE IWRGISVNIQ EMPINEAKQM GAMALFGEKY GDIVRVVNMA
670 680 690 700 710 720
PFSIELCGGI HVDNTAEIGL FKIISESGTG AGVRRIEAFT GKSAFLHLED IQNKFNSIKD
730 740 750 760 770 780
QVKVKSDNQV FDKIVQLQEE EKNLHKQLEQ RNKEITSLKM GNIEDQIEEI NGFKVLATEV
790 800 810 820 830 840
EVSNAKEIRQ TMDDFKSKQQ DAIIILASDL GEKVSLIATV PKEQTDKIKA GDIIKNMAPL
850 860 870
VGGKGGGRPD MAQGGGTQPE NISEALRFIK DYIKKL