Q4L3G0
Gene name |
mfd |
Protein name |
Transcription-repair-coupling factor |
Names |
TRCF |
Species |
Staphylococcus haemolyticus (strain JCSC1435) |
KEGG Pathway |
sha:SH2508 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4L3G0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4L3G0-F1 | Predicted | AlphaFoldDB |
No variants for Q4L3G0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4L3G0 | |||||
No associated diseases with Q4L3G0
6 regional properties for Q4L3G0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal | 809 - 970 | IPR001650 |
| domain | CarD-like/TRCF, RNAP-interacting domain | 495 - 592 | IPR003711 |
| domain | Transcription-repair-coupling factor, C-terminal domain | 1021 - 1121 | IPR005118 |
| domain | DEAD/DEAH box helicase domain | 621 - 780 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 616 - 806 | IPR014001 |
| domain | UvrB, interaction domain | 139 - 227 | IPR041471 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| damaged DNA binding | Binding to damaged DNA. |
| helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| transcription-coupled nucleotide-excision repair, DNA damage recognition | The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRPIISDYIQ | NDKRFQELDD | VFGHQNILVT | GLSPSAKATI | IAEKYLKDQK | QMLLITNNLY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QADKLETDIL | QYIDHSEVYK | YPVQDIMTEE | FSTQSPQLMS | ERVRTLTALA | HNKKGLFIVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LNGLKKWLTP | FELWKDHQIT | LRVGEDIDVD | EFLNKLVNMG | YRRESVVSHI | GEFSLRGGII |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DIYPLIGQPV | RIELFDTEVD | SIRDFDVETQ | RSNDNIEEVS | ITTASDYVIT | DDVIQHLQSE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LKTAYEATRP | KIDKSVRNDL | KETYESFKLF | ETTFFDHQLL | RRLVAFMYEQ | PSTLIDYFAK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DAIIVADEYN | RIKETEKTLT | TEVDDFIQNL | IESGNGFIGQ | SFMQYDGFES | LLKDYPVTYF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLFTSTMPVQ | LQHIIKFSCK | PVQQFYGQYD | IMRSEFQRYV | HNDYHIVVLV | ETETKVERIQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SMLNEMHIPT | VTNVQNDIKS | GQVVVTEGSL | SEGFELPYMQ | LVVITERELF | KTKQKKQRKR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TKTLSNAEKI | KSYQDLNVGD | YVVHVHHGVG | RYLGVETLEV | GDVHRDYIKL | QYKGTDQLFV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PVDQMDQVQK | YVASEDKSPK | LNKLGGSEWK | KTKAKVQQSV | EDIADELIAL | YKEREMSVGY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QYGEDTAEQS | AFEMDFPYEL | TPDQAKSIDE | IKGDMERERP | MDRLLCGDVG | YGKTEVAVRA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AFKAVMEGKQ | VAFLVPTTIL | AQQHYETLIE | RMQDFPVQIE | LISRFRSTKE | VKETKEGLKS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GYVDIVVGTH | KLLGKDIHYK | DLGLLIVDEE | QRFGVRHKER | IKTMKTNVDV | LTLTATPIPR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TLHMSMLGVR | DLSVIETPPE | NRFPVQTYVL | EQNSNFIKEA | LERELSRDGQ | VFYLYNRVQS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IYEKREQLQM | LMPDANIAVA | HGQMTERDLE | ETMLSFINGE | FDILVTTTII | ETGVDVPNAN |
| 910 | 920 | 930 | 940 | 950 | 960 |
| TLIIEEADRF | GLSQLYQLRG | RVGRSSRIGY | AYFLHSANKV | LTETAEERLQ | AIKEFTELGS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GFKIAMRDLN | IRGAGNLLGK | QQHGFIDSVG | FDLYSQMLEE | AVNEKRGIKE | EEPDAPEVEM |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ELNLDAYLPA | EYIQNEQAKI | EIYKKLRKVE | TEEQLFDIKD | ELIDRFNDYP | VEVERLLEMV |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| EIKIHALHAG | VTLIKDKGKQ | IEVSLSTKAT | EQMNGEELFK | QTQPLGRAMK | LGVKENRMHV |
| 1150 | 1160 | ||||
| TLTKSKQWLD | NLKFLVRCLE | GSMVIEDEN |