Q4KI35

PR
Gene name
hmgA
Protein name
Homogentisate 1,2-dioxygenase
Names
HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase
Species
Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
KEGG Pathway
pfl:PFL_0967
EC number
1.13.11.5: With incorporation of two atoms of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4KI35

Entry ID Method Resolution Chain Position Source
AF-Q4KI35-F1 Predicted AlphaFoldDB

No variants for Q4KI35

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4KI35

No associated diseases with Q4KI35

4 regional properties for Q4KI35

Type Name Position InterPro Accession
domain Anticodon-binding 333 - 421 IPR004154
domain Aminoacyl-tRNA synthetase, class II 1 - 328 IPR006195
domain Histidyl-anticodon-binding 330 - 420 IPR033656
domain Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain 9 - 318 IPR041715

Functions

Description
EC Number 1.13.11.5 With incorporation of two atoms of oxygen
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
homogentisate 1,2-dioxygenase activity Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).
iron ion binding Binding to an iron (Fe) ion.

2 GO annotations of biological process

Name Definition
L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.
tyrosine catabolic process The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNLDSSASAL SYQSGFGNEF ASEALPGALP VGQNSPQKAP YGLYAELFSG TAFTMTRSEA
70 80 90 100 110 120
RRTWMYRIQP SAKHPAFAKL ARQLAGGPLG EVTPNRLRWS PLQIPSEPTD FIDGLVAMVA
130 140 150 160 170 180
NSAAQKPAGI SVYHYRANRS MERVFFNADG ELLLVPELGR LRIVTELGML DLEPLEIAVL
190 200 210 220 230 240
PRGLKFRIEL LDPQARGYVA ENHGAPLRLP DLGPIGSNGL ANPRDFLAPV AHYEDLRQPT
250 260 270 280 290 300
TLVQKYLGEL WGCELDHSPL NVVAWHGNNV PYKYDLRRFN TIGTVSFDHP DPSIFTVLTS
310 320 330 340 350 360
PTSVPGLANL DFVIFPPRWM VAENTFRPPW FHRNLMNEFM GLIQGAYDAK AEGFLPGGAS
370 380 390 400 410 420
LHSCMSAHGP DGETCTKAIN AQLQPAKIDN TMAFMFETSQ VLRPSQFALE CPELQNDYDA
430
CWASLPVTFN PNRR