Q4KHE3

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
KEGG Pathway
pfl:PFL_1209
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

770-846 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4KHE3

Entry ID Method Resolution Chain Position Source
AF-Q4KHE3-F1 Predicted AlphaFoldDB

No variants for Q4KHE3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4KHE3

No associated diseases with Q4KHE3

5 regional properties for Q4KHE3

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 610 - 799 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 12 - 123 IPR007695
domain DNA mismatch repair protein MutS, core 274 - 594 IPR007696
domain DNA mismatch repair protein MutS, connector domain 132 - 257 IPR007860
domain DNA mismatch repair protein MutS, clamp 431 - 521 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKNTSDLSS HTPMMQQYWR LKNQHPDQLM FYRMGDFYEI FYEDAKKAAK LLDITLTARG
70 80 90 100 110 120
QSAGQAIPMC GIPYHAAEGY LAKLVKLGES VVICEQVGDP ATSKGPVERQ VVRIITPGTV
130 140 150 160 170 180
SDEALLDERR DNLIAAVLGD ERLFGLAVLD ITSGNFSVLE IKGWENLLAE LERINPVELL
190 200 210 220 230 240
IPDDWPQGLP AEKRRGVRRR APWDFERDSA HKSLCQQFST QDLKGFGCET LTLAIGAAGC
250 260 270 280 290 300
LLSYAKETQR TALPHLRSLR HERLDDTVVL DGASRRNLEL DTNLAGGRDN TLQSVVDRCQ
310 320 330 340 350 360
TAMGSRLLTR WLNRPLRDLK VLEARQSSIT CLLDGYRFER LQPQLKEIGD IERILARIGL
370 380 390 400 410 420
RNARPRDLAR LRDALAALPE LQEAMTELEA THLNQLAATT STYPELAALL AKAIIDNPPA
430 440 450 460 470 480
VIRDGGVLKT GYDAELDELQ SLSENAGQFL IDLEAREKAR TGLANLKVGY NRIHGYFIEL
490 500 510 520 530 540
PSKQAEQAPA DYIRRQTLKG AERFITPELK EFEDKALSAK SRALAREKML YDALLETLIS
550 560 570 580 590 600
HLPPLQDTAG ALAELDVLSN LAERALNLDL NCPRFVSEPC MRITQGRHPV VEQVLTTPFV
610 620 630 640 650 660
ANDLSLDDNT RMLVITGPNM GGKSTYMRQT ALIVLLAHIG SFVPAASCEL SLVDRIFTRI
670 680 690 700 710 720
GSSDDLAGGR STFMVEMSET ANILHNATER SLVLMDEVGR GTSTFDGLSL AWAAAERLAH
730 740 750 760 770 780
LRAYTLFATH YFELTVLPES EPLVANVHLN ATEHNERIVF LHHVLPGPAS QSYGLAVAQL
790 800 810 820 830 840
AGVPSAVITR AREHLSRLET TSLPHEVAPQ APGKPSVPQQ SDMFASLPHP VLDDLAKLDL
850
DDMTPRRALE MLYTLKTRI