Q4JW94

PR
Gene name
murC
Protein name
UDP-N-acetylmuramate--L-alanine ligase
Names
UDP-N-acetylmuramoyl-L-alanine synthetase
Species
Corynebacterium jeikeium (strain K411)
KEGG Pathway
cjk:jk0751
EC number
6.3.2.8: Acid--amino-acid ligases (peptide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-91 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4JW94

Entry ID Method Resolution Chain Position Source
AF-Q4JW94-F1 Predicted AlphaFoldDB

No variants for Q4JW94

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4JW94

No associated diseases with Q4JW94

2 regional properties for Q4JW94

Type Name Position InterPro Accession
domain Mur ligase, C-terminal 307 - 376 IPR004101
domain Mur ligase, central 113 - 284 IPR013221

Functions

Description
EC Number 6.3.2.8 Acid--amino-acid ligases (peptide synthases)
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
UDP-N-acetylmuramate-L-alanine ligase activity Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanine.

5 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.
regulation of cell shape Any process that modulates the surface configuration of a cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDQLQTTDL SRVHMVGIGG AGMSGIARIL LDRGYQVSGS DMKESRSIMA LRAAGAQIQV
70 80 90 100 110 120
GHAEDNLRLS GEMPTVVVTS FAAIPQDNPE LVGAREAGIP VLRRSDILAL LLQDRRAFLL
130 140 150 160 170 180
AGTHGKTSTT SMAVAALQAA GQDPSFAIGG QLNRAGTNAH NGTGEVFVAE ADESDGSFLS
190 200 210 220 230 240
YSPEIAVVTN IEPDHLDYFK TESAYREVFE KFAHRIVPGG FLVVCLDDPG SAALAEELIA
250 260 270 280 290 300
GAEEGNPLPF TVVGYGTAEG CDAHPSVPPA AIIESTEVTA EGTVSALRLT EEVKKAAEEA
310 320 330 340 350 360
AGTYSLRVAI PGIHMVLNAA AAVLGSVLLG ADVDKVIAGI GGFDGVRRRF EYHGTRQDVE
370 380 390 400 410 420
VYDDYAHHPT EVAAVLAAAR QRVEARGGRI VAVFQPHLYS RTMNFADEFA EALSLADQVV
430 440 450 460 470 480
LLDIFGAREE PVEGVDSRII GNKIDASTDW VFEPDFSKVS SVVAGLVQPG DMVLTIGAGT
490
VTMLADEILL ELDRGDRG