Q4JW06

PR
Gene name
pheS
Protein name
Phenylalanine--tRNA ligase alpha subunit
Names
Phenylalanyl-tRNA synthetase alpha subunit, PheRS
Species
Corynebacterium jeikeium (strain K411)
KEGG Pathway
cjk:jk0839
EC number
6.1.1.20: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-99 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4JW06

Entry ID Method Resolution Chain Position Source
AF-Q4JW06-F1 Predicted AlphaFoldDB

No variants for Q4JW06

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4JW06

No associated diseases with Q4JW06

3 regional properties for Q4JW06

Type Name Position InterPro Accession
domain Phenylalanyl-tRNA synthetase 105 - 344 IPR002319
domain Phenylalanine-tRNA ligase, class II, N-terminal 33 - 100 IPR004188
domain Aminoacyl-tRNA synthetase, class II 125 - 346 IPR006195

Functions

Description
EC Number 6.1.1.20 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phenylalanine-tRNA ligase activity Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDSADTPQV ELSEQGLNAA ADAAEKAFAE AANLEELAAA RREHLGDDAP IPAARRSLGS
70 80 90 100 110 120
LPKDQRKDAG RLVNMARGRV EKRFAQVKAE LERKRNEEVL RAERIDVTEP TTRGQRGAQH
130 140 150 160 170 180
PITILSEQIA DIFVGMGWEI ADGPEVEAEY FNFDSLNFIP DHPARTLQDT FHIAPEGSGQ
190 200 210 220 230 240
VLRTHTSPVQ MRTMLSRDLP IYIACPGRVF RTDELDATHT PVFHQVEGLA VDKGLTMAHL
250 260 270 280 290 300
KGTLDHLAKT LFGEEAKTRI RPNYFPFTEP SAEVDVWFAD KKGGAGWIEW GGCGMVNPNV
310 320 330 340 350
LIAAGVDPEE YSGFAFGMGI ERTLQFRNGL PDMRDMVEGD VRFTLPFGVR R