Q4JVP8
Gene name |
pafA |
Protein name |
Pup--protein ligase |
Names |
Proteasome accessory factor A, Pup-conjugating enzyme |
Species |
Corynebacterium jeikeium (strain K411) |
KEGG Pathway |
cjk:jk0945 |
EC number |
6.3.1.19: Acid--ammonia (or amine) ligases (amide synthases) |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4JVP8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4JVP8-F1 | Predicted | AlphaFoldDB |
No variants for Q4JVP8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4JVP8 | |||||
No associated diseases with Q4JVP8
No regional properties for Q4JVP8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q4JVP8 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.1.19 | Acid--ammonia (or amine) ligases (amide synthases) |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ligase activity, forming carbon-nitrogen bonds | Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| ubiquitin-like protein transferase activity | Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| modification-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. |
| proteasomal protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. |
| protein pupylation | The process in which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of Pup and the epsilon-amino group of a lysine residue of the target protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTAIRRRIMG | LETEYGIANM | QDSSRRLGPD | EIARKLFAPV | VEKHRSSNIY | TENASRLYLD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VGAHPEFATA | ECDSLHQLIA | YDRSGDLMFH | ELADRAEQAV | GGKVYLLKNN | TDSLGNSYGC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HENYLVSRDI | PLKGLSKQLL | PFLVTRQLIC | GAGKLAIPYP | GAPNENFGPG | YTMSQRADHV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WEGVSSATTR | SRPIINTRDE | PHADSSKYRR | LHVIVGDSNM | SEVTTALKVG | STLLVLEMIE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AGVALPDFEM | ANEIRSIREI | SRDFTGQVDI | ALRSGSTATP | LEIQRAFYDA | ACAYLASRED |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PERGTPNAEL | TPVVDLWGRV | LDCFDTGDFS | PVSTEIDWVI | KKSLLDRMAA | ARGLDPIDPR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LAQIDLMYHD | IHPTRGLFNV | LARRGLARTL | LAPETIEQAV | RQAPPTTRAA | VRGRFIAAVR |
| 430 | 440 | 450 | 460 | ||
| ANPELSYTVD | WMRVKVNGEG | GAEALLADPF | ANTSEDVDRI | IESLESR |