Q4JUQ7

PR
Gene name
gltX
Protein name
Glutamate--tRNA ligase
Names
Glutamyl-tRNA synthetase, GluRS
Species
Corynebacterium jeikeium (strain K411)
KEGG Pathway
cjk:jk1281
EC number
6.1.1.17: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

83-178 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4JUQ7

Entry ID Method Resolution Chain Position Source
AF-Q4JUQ7-F1 Predicted AlphaFoldDB

No variants for Q4JUQ7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4JUQ7

No associated diseases with Q4JUQ7

3 regional properties for Q4JUQ7

Type Name Position InterPro Accession
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain 6 - 326 IPR020058
domain Glutamyl-tRNA synthetase 6 - 335 IPR033910
domain Aminoacyl-tRNA synthetase, class I, anticodon-binding 343 - 489 IPR045462

Functions

Description
EC Number 6.1.1.17 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamate-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEVSEVRVR FCPSPTGTPH VGMVRTALFN WAYARHTGGK LVFRIEDTDA KRDSEESYQA
70 80 90 100 110 120
IIDSLKWLNL GWDEGIEVGG PHEPYRQSQR MDIYADVLEK LKESGDVYPA YSTNEEVQAR
130 140 150 160 170 180
HKAAGRDPQL GYDNYDRDLT EEQIAQFKAE GREPVWRLRM PDNRIYEWHD LVRGDMSVDG
190 200 210 220 230 240
KTVPDFVVAR SNGQPLYTLV NPVDDALMEI THVLRGEDLL PSTPRQIALY EALVRVGVAK
250 260 270 280 290 300
QVPTFGHLPF VMGEGNKKLS KRDPESNLFN HRDNGIIPEG MLNYLSLLGW SLSADEDIFT
310 320 330 340 350 360
MQQLIDNFDV ADVKPNPARF DQKKLEAINA DHIRMLELGD FTERLRAYLE EYKGFPADYP
370 380 390 400 410 420
ADKFAFAAEL VQTRIKTLSD ADGLLRFLIT SDADLSLDEK AARKNLKEDA VEVLEVAIAQ
430 440 450 460 470 480
LEAIADGEFK TDVIEKALQS KLIEEMELKP RKAYGALRVA ISGAAVSPPL FESMELLGKE
490
STLARLRAAR EQTPFAPAQQ