Q4JQX0

PR
Gene name
gK (ORF5)
Protein name
Envelope glycoprotein K
Names
Syncytial protein
Species
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)
KEGG Pathway
vg:1487673
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

300-340 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q4JQX0

Entry ID Method Resolution Chain Position Source

No variants for Q4JQX0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4JQX0

No associated diseases with Q4JQX0

No regional properties for Q4JQX0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q4JQX0

Functions

Description
EC Number
Subcellular Localization
  • Host cell membrane ; Multi-pass membrane protein
  • Host endosome membrane ; Multi-pass membrane protein
  • Host Golgi apparatus membrane ; Multi-pass membrane protein
  • During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs
  • It is probably transported with UL20 to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN)
  • Cell surface expression of gK is required for virus-induced cell-to-cell fusion
  • Likely not present in extracellular virions (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
host cell endosome membrane The lipid bilayer surrounding a host cell endosome.
host cell Golgi membrane The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus.
host cell plasma membrane The plasma membrane surrounding a host cell.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
fusion of viral membrane with host outer nuclear membrane Fusion of a viral primary envelope with the host outer nuclear membrane during nuclear egress. The transitory primary envelope is acquired by the virus as it buds at the inner nuclear membrane and gains access to the perinuclear space. This membrane is lost by fusing with the host outer nuclear membrane during nuclear exit.
positive regulation of syncytium formation by virus The process in which a virus increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQALGIKTEH FIIMCLLSGH AVFTLWYTAR VKFEHECVYA TTVINGGPVV WGSYNNSLIY
70 80 90 100 110 120
VTFVNHSTFL DGLSGYDYSC RENLLSGDTM VKTAISTPLH DKIRIVLGTR NCHAYFWCVQ
130 140 150 160 170 180
LKMIFFAWFV YGMYLQFRRI RRMFGPFRSS CELISPTSYS LNYVTRVISN ILLGYPYTKL
190 200 210 220 230 240
ARLLCDVSMR RDGMSKVFNA DPISFLYMHK GVTLLMLLEV IAHISSGCIV LLTLGVAYTP
250 260 270 280 290 300
CALLYPTYIR ILAWVVVCTL AIVELISYVR PKPTKDNHLN HINTGGIRGI CTTCCATVMS
310 320 330
GLAIKCFYIV IFAIAVVIFM HYEQRVQVSL FGESENSQKH