Q4JCI5

PR
Gene name
lysS
Protein name
Lysine--tRNA ligase
Names
Lysyl-tRNA synthetase, LysRS
Species
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
KEGG Pathway
sai:Saci_0067
EC number
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

305-430 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4JCI5

Entry ID Method Resolution Chain Position Source
AF-Q4JCI5-F1 Predicted AlphaFoldDB

No variants for Q4JCI5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4JCI5

No associated diseases with Q4JCI5

9 regional properties for Q4JCI5

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (D/K/N) 152 - 492 IPR004364
domain OB-fold nucleic acid binding domain, AA-tRNA synthetase-type 61 - 136 IPR004365
domain Aminoacyl-tRNA synthetase, class II 183 - 488 IPR006195
domain Lysyl-tRNA synthetase, class II, C-terminal 188 - 198 IPR018149-1
domain Lysyl-tRNA synthetase, class II, C-terminal 204 - 220 IPR018149-2
domain Lysyl-tRNA synthetase, class II, C-terminal 233 - 246 IPR018149-3
domain Lysyl-tRNA synthetase, class II, C-terminal 251 - 268 IPR018149-4
domain Lysyl-tRNA synthetase, class II, C-terminal 377 - 393 IPR018149-5
domain Lysine-tRNA ligase, class II, N-terminal 59 - 162 IPR044136

Functions

Description
EC Number 6.1.1.6 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
magnesium ion binding Binding to a magnesium (Mg) ion.
nucleic acid binding Binding to a nucleic acid.

1 GO annotations of biological process

Name Definition
lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFHIIDLALK WDERRVKIVD ELKSKGINPY PHKYDITHTI IDIKKMERSD KPTDAFAFDI
70 80 90 100 110 120
STAGRVANIR RHGKISFVDI FDEGERLQLQ LRVNELGDRY DKFFEIVDRG DILGVKGDLL
130 140 150 160 170 180
YTIKGELTLR IKDYVLLSKS LIEPPDWSKL SPEFRYAHRY VDFLYNDLAR RNMEIRYSTI
190 200 210 220 230 240
RRIREFLYSK GFMEVETPIL QPVYGGALAK PFMSHVNYLN ENWYLRISLE LYLKRYIVGG
250 260 270 280 290 300
FNKVFEIGKV FRNEDIDVTH NPEFTLLELY WAYADYNDIM RLTEEMLQDV VKNINNDSKI
310 320 330 340 350 360
KYSIGGKEYT IEFSQFRKIT MIDSLTEVLG KDVDKMSDEE LKSLMDKNGL KPRGNMYIRG
370 380 390 400 410 420
LMIEKLFDKL VTPTLIQPTF VLDYPVETTP LCKPHRSKQG LVERFELYVA GMELANAYTE
430 440 450 460 470 480
LNDPIIQDML FKQEQEMFKR GDEEAHPYDV DFVRALSYGM PPTGGLGIGI DRLIMLLTNN
490
MSIKEIIPYP MLSAKVIQED