Q4JCH6

PR
Gene name
tyrS
Protein name
Tyrosine--tRNA ligase
Names
Tyrosyl-tRNA synthetase, TyrRS
Species
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
KEGG Pathway
sai:Saci_0076
EC number
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

186-268 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4JCH6

Entry ID Method Resolution Chain Position Source
AF-Q4JCH6-F1 Predicted AlphaFoldDB

No variants for Q4JCH6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4JCH6

No associated diseases with Q4JCH6

2 regional properties for Q4JCH6

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 52 IPR001412
domain RNA-binding S4 domain 336 - 398 IPR002942

Functions

Description
EC Number 6.1.1.1 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tyrosine-tRNA ligase activity Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNIDEKIKLI TRNTDEVITI DELKKKLEEN SKLKGYIGFE PSGLFHIGWL IWAQKLKDLI
70 80 90 100 110 120
KAGVDMSILV ATWHAMINDK LGGDLEKIKL AGKYALEVLE GFGVDMSKLK VVYAEDLVEN
130 140 150 160 170 180
IDYWSLVVKV AKNTSLARMK RALTIMGRRS EEAELDTSKL IYPAMQVSDI FFQDLDIALG
190 200 210 220 230 240
GTDQRKAHML ARDVAEKLQR KKVIAIHTPL LVGLQGGQRM NTEGLEEDDY LATIKMSKSK
250 260 270 280 290 300
PETAIFIHDS PELVESKLKN SYCPKGVVND NPVLQINKYI IFGEQGVTLK IERDTKYGGD
310 320 330 340 350 360
IEIKSYEELE RIFIEGKLHP LDLKLATARK LNDILDPIRK RISSKSQFVD LISSIEKSIT
R