Q4JC68
Gene name |
Saci_0192 |
Protein name |
ATP-dependent DNA helicase Saci_0192 |
Names |
|
Species |
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) |
KEGG Pathway |
sai:Saci_0192 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q4JC68
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3CRV | X-ray | 200 A | A | 1-551 | PDB |
| 3CRW | X-ray | 400 A | 1 | 1-551 | PDB |
| 5H8C | X-ray | 229 A | A | 3-551 | PDB |
| AF-Q4JC68-F1 | Predicted | AlphaFoldDB |
No variants for Q4JC68
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4JC68 | |||||
No associated diseases with Q4JC68
5 regional properties for Q4JC68
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase-like, DEXD box c2 type | 3 - 234 | IPR006554 |
| domain | ATP-dependent helicase, C-terminal | 386 - 540 | IPR006555 |
| domain | RAD3-like helicase, DEAD | 88 - 189 | IPR010614 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 16 - 343 | IPR014001 |
| domain | Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type | 1 - 228 | IPR014013 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| 5'-3' DNA helicase activity | Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA duplex unwinding | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLKLRDWQEK | LKDKVIEGLR | NNFLVALNAP | TGSGKTLFSL | LVSLEVKPKV | LFVVRTHNEF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YPIYRDLTKI | REKRNITFSF | LVGKPSSCLY | AEKGAESEDI | PCKYCELKGS | IVEVKTDDSP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSLVKKLKKD | GLQDKFCPYY | SLLNSLYKAD | VIALTYPYFF | IDRYREFIDI | DLREYMIVID |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EAHNLDKVNE | LEERSLSEIT | IQMAIKQSKS | EESRRILSKL | LNQLREVVLP | DEKYIKVENV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PKLSKEELEI | LADDYEDIRK | DSLKQGKVNK | IHIGSILRFF | SLLSIGSFIP | FSYSKRLVIK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NPEISYYLNL | LNDNELSIIL | MSGTLPPREY | MEKVWGIKRN | MLYLDVEREI | QKRVSGSYEC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YIGVDVTSKY | DMRSDNMWKR | YADYLLKIYF | QAKANVLVVF | PSYEIMDRVM | SRISLPKYVE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SEDSSVEDLY | SAISANNKVL | IGSVGKGKLA | EGIELRNNDR | SLISDVVIVG | IPYPPPDDYL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KILAQRVSLK | MNRENEEFLF | KIPALVTIKQ | AIGRAIRDVN | DKCNVWLLDK | RFESLYWKKN |
| 550 | |||||
| LKCLNANKMK | L |