Q4I5R3

PR
Gene name
SET1 (FGRRES_16832, FGSG_07445)
Protein name
Histone-lysine N-methyltransferase, H3 lysine-4 specific
Names
COMPASS component SET1, SET domain-containing protein 1
Species
Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)
KEGG Pathway
fgr:FGSG_07445
EC number
2.1.1.354: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-268 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4I5R3

Entry ID Method Resolution Chain Position Source
AF-Q4I5R3-F1 Predicted AlphaFoldDB

No variants for Q4I5R3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4I5R3

No associated diseases with Q4I5R3

4 regional properties for Q4I5R3

Type Name Position InterPro Accession
domain SET domain 1121 - 1244 IPR001214
domain Post-SET domain 1247 - 1263 IPR003616
domain Histone lysine methyltransferase SET associated 471 - 540 IPR024636
domain COMPASS complex Set1 subunit, N-SET domain 944 - 1115 IPR024657

Functions

Description
EC Number 2.1.1.354 Methyltransferases
Subcellular Localization
  • Nucleus
  • Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
Set1C/COMPASS complex A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

1 GO annotations of molecular function

Name Definition
histone methyltransferase activity (H3-K4 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein.

2 GO annotations of biological process

Name Definition
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
histone H3-K4 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTRPPGASFA EFFPTAPKVK AQAQTRADQV RDRDRFKTAS TPATINGTID STTGTAVLEA
70 80 90 100 110 120
DANVSLNGIV SASDTMPTQP DDTESPFTDI PNTVDSASSY SSAASSIFST STRHGAAATT
130 140 150 160 170 180
ASSRLPTSSL TPSAFKESPN SAPAAAKPDM STYQTSDRAA RQSSRNSPAT GPNVSISNGL
190 200 210 220 230 240
PSNERIPARD PLPSVKGLRC TYDPLLDRVH NKSVSKSAKP TYEEFGREDD APPPKDPRLA
250 260 270 280 290 300
RSDGRLGYIN TDYYLPKSRL RTAPENIKPY PYDPKTSIGP GPPTQIVVTR YNPLIPFSKV
310 320 330 340 350 360
TAIFASFGEI AESSNKMHPE TGSYLGFATI RYRDSKRPDR PPVSGIDAAR RAVRARGIKV
370 380 390 400 410 420
DADIVRVEYD AEGRRSRRML EEHLKREKEK FEKIEQERLA LAAKAPPTGP KSGTAPAFTR
430 440 450 460 470 480
PPPTAPKGPS AQRQSIPTGT PQIPLLGTQV QGLNLEPSNL AQKLADDPYI YVTGDSVPVL
490 500 510 520 530 540
PSILPHMKKR LKSYGFEEIR VDKSGYFIVF RNSFTGSSEA ERCFRAVNHT EFFNYDMTMQ
550 560 570 580 590 600
LCLPRPRRED GSGRRRSSAS SDRHTHAEPR YRDEKDRRRR EEEADLEEEK KQRAKNFDPV
610 620 630 640 650 660
IEAVEVVRRE MMEHLIRHIR TKVAAPALSD FLDPANHAAK RRKLNIEHPD DLQEIPSIED
670 680 690 700 710 720
GNDSSRVGTP NSRADPIERR TGRLEPKALP RIRKTKVKGQ AQKSAFVDPF ARKRPPVARN
730 740 750 760 770 780
AFRSLHHRLR SLDSDAESDD DTDTRALLAR ETEEADSRPR SRMSTDDEAS KDDFVPWEQG
790 800 810 820 830 840
EDDSMTEASF AIADTASTRK RKLVASLESV FKRQKKSDEE LFGVNLETLD SEFKGREDSV
850 860 870 880 890 900
DIIPEPETGD DVESRVSRSE TPASAIGKPL KKRPGKRKKT KKASFEEPEA AKTQPETEQQ
910 920 930 940 950 960
PGDEATEPSK VKQEKAEKTS MEELVPEKFD EKLFATEPLT PALELPEGAK PDLPIFQGLT
970 980 990 1000 1010 1020
VSAQDIPDLA KLARRFNTKD IGNAELWLWT RNRIRELNSA RRTLDSPVTI GGYYVPNPTG
1030 1040 1050 1060 1070 1080
CARTEGVKKI LNSEKSKYLP HHIKVQKARQ EREARNKLGR DAAAEAADAA RIAAEKLVAK
1090 1100 1110 1120 1130 1140
GNSRANRATN RRYVADLNDQ KKTLGQDSDV FKFNQLKKRK KPVKFARSAI HNWGLYAMEN
1150 1160 1170 1180 1190 1200
IAKDDMIIEY VGEQVRQQIS EIRENRYLKS GIGSSYLFRI DDNTVIDATK KGGIARFINH
1210 1220 1230 1240 1250 1260
SCMPNCTAKI IKVEGSKRIV IYALRDIALN EELTYDYKFE REIGSTDRIP CLCGTAACKG
FLN