Q4H3K6

PR
Gene name
FGFR
Protein name
Fibroblast growth factor receptor
Names
Ci-FGFR
Species
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
KEGG Pathway
cin:445706
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-87 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4H3K6

Entry ID Method Resolution Chain Position Source
AF-Q4H3K6-F1 Predicted AlphaFoldDB

No variants for Q4H3K6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4H3K6

No associated diseases with Q4H3K6

12 regional properties for Q4H3K6

Type Name Position InterPro Accession
domain Protein kinase domain 377 - 660 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 379 - 656 IPR001245
domain Immunoglobulin subtype 2 90 - 158 IPR003598-1
domain Immunoglobulin subtype 2 189 - 258 IPR003598-2
domain Immunoglobulin subtype 83 - 169 IPR003599-1
domain Immunoglobulin subtype 183 - 269 IPR003599-2
domain Immunoglobulin-like domain 74 - 167 IPR007110-1
domain Immunoglobulin-like domain 175 - 267 IPR007110-2
active_site Tyrosine-protein kinase, active site 521 - 533 IPR008266
domain Immunoglobulin I-set 91 - 168 IPR013098-1
domain Immunoglobulin I-set 183 - 268 IPR013098-2
domain Tyrosine-protein kinase, catalytic domain 377 - 656 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fibroblast growth factor binding Binding to a fibroblast growth factor.
fibroblast growth factor receptor activity Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

3 GO annotations of biological process

Name Definition
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of kinase activity Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIQLQNTFIF IALTIFTSAS TTSLKNETKP LNTISTLAAQ TNISNPEEDL FDTNGAPKSD
70 80 90 100 110 120
TVNASTTTDR HKIPRWVNEQ KMQKRLHAEP AGNTVQFRCA VQGARPITVD WYKDGEPIKK
130 140 150 160 170 180
NGRLGGYKFR QRNQQISLES VIMSDRAKYM CVAHNKYGSI NHTYELDVVA RIPIPPVLSA
190 200 210 220 230 240
DGMKNQTVKV GSTVTFRCRI VYSDAHPHVE WLKYNVNVTV LKRAGINTTD AEMEKLTLKN
250 260 270 280 290 300
VSFADAGEYT CLAGNSIGVS HVSAWLTVLP VVDENDVWTE EIPQDTHYLI YIFGVVCFII
310 320 330 340 350 360
LLAFIVYMCN SRYQNKDPPR LIPIENPDNI PPMSKMEEPV MLFGNEQAWR RMCLPHADHI
370 380 390 400 410 420
EINIQPDLQW ELKREDILLH ERIDEGFFGQ VFRADLIRCA GGRKEKVDAA VKMLKSTRTE
430 440 450 460 470 480
KDMLDLLTEM DQMKRVGKHK NIVNLLGVCT QNGILWLVTE YAQKGNLRDY LRRNRPSELQ
490 500 510 520 530 540
YELSTPDSPA PPRDEPLTLR ALMSASHQVA RGMEYLSQKK CIHRDLAARN VLVANDFVMK
550 560 570 580 590 600
IADFGLARDI RSNDYYRKET RGHLPYKWMA LEAMTDNMFT HATDVWSFGI LLWEIFSLGG
610 620 630 640 650 660
SPYPGVKTHD LVRFLRNGDR LEQPQFASSE LYRLMRDCWE ESPRRRPQFR QLVEDLDRML
670 680 690 700 710 720
ASSSSLEYID LNSPCEADYL PSDVDSNEDT ESRDSANATG EDSDSVFEPI DGHGAHAYEV
730 740
DEAGPLLNPQ PDANIVCNGH ARMQSDV