Q4H0T5

PR
Gene name
TFAM
Protein name
Transcription factor A, mitochondrial
Names
ATP-binding cassette sub-family G member 2, Urate exporter, mtTFA
Species
Trachypithecus cristatus (Silvered leaf-monkey) (Presbytis cristata)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

38-246 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4H0T5

Entry ID Method Resolution Chain Position Source
AF-Q4H0T5-F1 Predicted AlphaFoldDB

No variants for Q4H0T5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4H0T5

No associated diseases with Q4H0T5

2 regional properties for Q4H0T5

Type Name Position InterPro Accession
domain High mobility group box domain 49 - 119 IPR009071-1
domain High mobility group box domain 154 - 220 IPR009071-2

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Mitochondrion matrix, mitochondrion nucleoid
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial nucleoid The region of a mitochondrion to which the DNA is confined.

3 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
mitochondrial promoter sequence-specific DNA binding Binding to a DNA region that controls the transcription of the mitochondrial DNA.
mitochondrial transcription factor activity Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase.

3 GO annotations of biological process

Name Definition
mitochondrial transcription The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
transcription initiation at mitochondrial promoter A transcription initiation process that takes place at a promoter on the mitochondrial chromosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAFLRSMWGV LSALGRSGAA VCIGCGSRLR SPFSFVYLPK CFSSVLASCP KKPVSSYLRF
70 80 90 100 110 120
SKEQLPIFKA ENPDAKPTEL IRRIAKLWRE LPDSKKKIYQ DAYRADWQVY KEKISRFKEQ
130 140 150 160 170 180
LTPSQITSLE KEIMDKHLKR KAMTKRKELT QLGKPKRPRS AYNVYVAEKF QEAKGDSPQE
190 200 210 220 230 240
KLKTVKENWK NLSDSEKELY IRLAKEDEIR YHNEMKSWEE QMIEAGRKDL LRRTIKQRQK
YGAEEY