Q4FVJ8

PR
Gene name
thiC
Protein name
Phosphomethylpyrimidine synthase
Names
Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC
Species
Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4)
KEGG Pathway
par:Psyc_0086
EC number
4.1.99.17: Other carbon-carbon lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4FVJ8

Entry ID Method Resolution Chain Position Source
AF-Q4FVJ8-F1 Predicted AlphaFoldDB

No variants for Q4FVJ8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4FVJ8

No associated diseases with Q4FVJ8

No regional properties for Q4FVJ8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q4FVJ8

Functions

Description
EC Number 4.1.99.17 Other carbon-carbon lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
carbon-carbon lyase activity Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
thiamine diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTISDIGSQA STTTSSKATA KADALKTPAH RSETDARFEE DARDLHRILP ASRKVYIEGS
70 80 90 100 110 120
RPDIQVPMRE ITLDPTPIQG VPESEWEQNP PFYVYDTSGV YTDPNTTIDL TKGLPKLREE
130 140 150 160 170 180
WIKERGDTEQ LSGLSSDYGQ ARARDISTAN LRFAHIDKPR RAKAVDGKVG NVTQMHYARR
190 200 210 220 230 240
GIITPEMEYI AIRETQKQHE LTDMRQHEGE TFGAHTPAII TPEFVRSEVA AGRAIIPNNI
250 260 270 280 290 300
NHPESEPMII GRNFLVKINA NIGNSALGSS IDEEVSKMTW ATRWGADNIM DLSTGNHIHE
310 320 330 340 350 360
TREWLIRNSP VPIGTVPIYQ ALEKVDGVAE DLTWEIFRDT LIEQAEQGVD YFTIHAGVLL
370 380 390 400 410 420
RYVPLTANRL TGIVSRGGSI MAQWCLAHHK ESFLYTHFED ICEIMKQYDV AFSLGDGLRP
430 440 450 460 470 480
GCLQDANDEA QFGELRTLGE LTQVAWKHDV QVMIEGPGHV AMNRIKENMD LQLETCADAP
490 500 510 520 530 540
FYTLGPLTTD IAPGYDHITS AIGAAMIGWF GTAMLCYVTP KEHLGLPNKK DVKDGIITYK
550 560 570 580 590 600
IAAHAADLAK GHPGAQARDN ALSKARFEFR WDDQFNLALD PDTAREFHDE TLPKDAHKSA
610 620 630 640 650 660
HFCSMCGPKF CSMKITQNVR DYAAGLKTLA DTKNSVSPQS GALNDAEHLI KKVDTQLVEQ
670 680 690
VGSASAEEIH QGMAEMTEKY HKEGRQLYKE V