Q4FVA9

PR
Gene name
hemA
Protein name
Glutamyl-tRNA reductase
Names
GluTR
Species
Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4)
KEGG Pathway
par:Psyc_0176
EC number
1.2.1.70: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

398-459 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4FVA9

Entry ID Method Resolution Chain Position Source
AF-Q4FVA9-F1 Predicted AlphaFoldDB

No variants for Q4FVA9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4FVA9

No associated diseases with Q4FVA9

3 regional properties for Q4FVA9

Type Name Position InterPro Accession
active_site Ferrochelatase, active site 189 - 207 IPR019772
domain Ferrochelatase, C-terminal 170 - 303 IPR033644
domain Ferrochelatase, N-terminal 6 - 165 IPR033659

Functions

Description
EC Number 1.2.1.70 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
glutamyl-tRNA reductase activity Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H(+) + NADPH.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

1 GO annotations of biological process

Name Definition
protoporphyrinogen IX biosynthetic process The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRLVVIGVNH KTAPVALRER LALVGDDVNI ALAQLQGFSD GSVIVSTCNR TEIYALVPES
70 80 90 100 110 120
ILSPNTLLAS SALSVVESSI SLNSSTNISS TIISAHILKI KTWLADFKQL SLDEIDPYLY
130 140 150 160 170 180
VHRDMHALTH WLRVAAGLDS MILGEPQILG QIKRAVHLAQ DQKALSNQLG WIVDQVFAAA
190 200 210 220 230 240
KRVRNETQVG AQAVSLSYAA AKLVTQIFDD LPSRTLLVVA AGEMNRLVAM HIAGLGVGRI
250 260 270 280 290 300
IICNRNPERA EALAAELRNP KRQIEVRTLQ ELPQVLAEAD IVSSCSGSMD ILIDKTMTLR
310 320 330 340 350 360
ALKSRRYQPM LMIDLAVPRD IDSTVSRIDD VYLYSVDDLQ HVIAGNIEQR RQAAVDAELL
370 380 390 400 410 420
VSQLVVEMDR RFQVRQVGKD IQQYRSRTHE QVDKLLQESI AKLQGDNANP EDIMIELTRR
430 440 450
LTQNLTHAPS KLMRKAAREG DNELLDFVVS GLQDAHRHH