Q4FQH3
Gene name |
rpoB |
Protein name |
DNA-directed RNA polymerase subunit beta |
Names |
RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta |
Species |
Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4) |
KEGG Pathway |
par:Psyc_1887 |
EC number |
2.7.7.6: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4FQH3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4FQH3-F1 | Predicted | AlphaFoldDB |
No variants for Q4FQH3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4FQH3 | |||||
No associated diseases with Q4FQH3
8 regional properties for Q4FQH3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA-directed RNA polymerase, subunit 2, hybrid-binding domain | 736 - 1293 | IPR007120 |
| conserved_site | RNA polymerase, beta subunit, conserved site | 1094 - 1106 | IPR007121 |
| domain | RNA polymerase Rpb2, domain 7 | 1295 - 1369 | IPR007641 |
| domain | RNA polymerase Rpb2, domain 2 | 159 - 231 | IPR007642-1 |
| domain | RNA polymerase Rpb2, domain 2 | 360 - 473 | IPR007642-2 |
| domain | RNA polymerase, beta subunit, protrusion | 26 - 518 | IPR007644 |
| domain | RNA polymerase Rpb2, domain 3 | 532 - 599 | IPR007645 |
| domain | DNA-directed RNA polymerase, beta subunit, external 1 domain | 610 - 675 | IPR019462 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.6 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| DNA-directed RNA polymerase complex | A protein complex that possesses DNA-directed RNA polymerase activity. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| ribonucleoside binding | Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAYSYTEKKR | IRKSFAELPT | VMDIPYLLSI | QVDSYEQFLQ | EHKKPKAREN | TGLQAAYSSI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FPIESHSGNA | ELQFVEYYLG | TPEFDERECI | LRGSTFAAPM | RVKIRLIIKD | KDSKDKDSKA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AIKDIREQSV | YMGEMPLMTA | NGTFIINGTE | RVIVSQLHRS | PGVFFDHDKG | KSHSSGKVLY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NARIIPYRGS | WLDFEFDAKD | LVFARIDRRR | KLLASIILRA | LGLSTSEILD | LFFDKVKVYK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GEEQFEIDLV | ADRLRGEMAQ | FDIVTPEGDV | VVEQGKRINA | RRIRQLEEAG | MTKISIPDEY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LYERILAEDI | IVNDEVIARA | NTLIDHELLV | KLSAFEASES | IKEFSILFTN | DIDQGSYIAD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLRADSTSSR | EEALIEIYKV | MRPGEPPTVE | TAEKLFDSMF | FNADRYDLSN | VGRMKFNRRL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GLDFVDTDDA | DIQRERSVLT | NADIVNVLKE | LIEIRNGRGE | VDDIDHLGNR | RIRSVGEMAE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NQFRVGLVRV | ERAVKERLSS | AESDNLSPQD | LINSKPVAAA | VKEFFGSSQL | SQFMDQNNPL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SEVTHKRRVS | ALGPGGLTRE | RAGFEVRDVH | DTHYGRVCPI | ETPEGPNIGL | INSLATFAKT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NSFGFLETPY | RRVVDGKVTD | VIEYLSAIEE | VGTVIAQADS | PVTADGALSD | EMVSVRSYGE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FVRMPPEKVT | HMDVSPSQVV | SVAAGLIPFL | EHDDANRALM | GSNMQRQAVP | TLRADKPLVG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TGMERHVARD | SGVCVIAKRG | GVIEDVDASR | IVVRVNEAEM | IAGEAGIDIY | NLVKYTRSNQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NTCINQRIIV | NQGDEIAFGD | ILADGPSTDL | GELALGQNIR | IAFMPWNGYN | FEDSILLSEK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VVKEDRFTTI | HIQELTCVAR | DTKLGTEEIT | ADIPNVGEAA | LSSLDEAGIV | YIGAEVDAGD |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ILVGKVTPKG | ETQLTPEEKL | LRAIFGEKAA | DVKDTSLRVP | TSSKGTVIDV | QVFTRDGVEK |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| DARARAIEKS | QLDSYRKDLK | EELRIFEEAA | RGRIGNLLDG | QKVSGGSGLK | AGTIMALADM |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| KDMSLETLLD | IQPVEEEISE | RLTQIAEYLV | DKQKDIDVKF | AEKKRKLTAG | DDLQHGVQKI |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| VKVYLAVKRR | IQPGDKMAGR | HGNKGVVSRI | MPVEDMPYDE | HGNTVDIVLN | PLGVPSRMNI |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| GQVLETHLGM | AAKGLGEKID | GMLKSQAAIK | DLREFLDKIY | NQVGGEQVDL | DSLTDDDIMA |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LADNLRAGVP | MGTAVFDGAK | ESQVKDLLEL | AGMDRDGQQT | LYDGRTGQKF | DRKVTVGYMY |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| MLKLNHLVDD | KMHARSTGSY | SLVTQQPLGG | KAQFGGQRFG | EMEVWALEAY | GATYTLQEML |
| 1330 | 1340 | 1350 | 1360 | 1370 | |
| TVKSDDVEGR | TRMYKNIVDG | EQYMDPGMPE | SFNVLTKEIK | SLGINIELKQ | TH |