Q4FPA9

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Pelagibacter ubique (strain HTCC1062)
KEGG Pathway
pub:SAR11_0158
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

792-865 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4FPA9

Entry ID Method Resolution Chain Position Source
AF-Q4FPA9-F1 Predicted AlphaFoldDB

No variants for Q4FPA9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4FPA9

No associated diseases with Q4FPA9

4 regional properties for Q4FPA9

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 56 - 67 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 26 - 643 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 689 - 842 IPR013155
domain Isoleucyl tRNA synthetase type 1, anticodon-binding domain 642 - 821 IPR033708

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKENINLPK TAFSMKANLQ NKEPEILEYW KKIDLYKELR KSNKGKEKFI LHDGPPYANG
70 80 90 100 110 120
NIHMGTALNK ILKDIIVKFH QMDGKDSVYV PGWDCHGLPI EWKIEEQYKK NKKNKNEVPI
130 140 150 160 170 180
TEFRKECREF AEKWIEVHKT QFKRLGVVGD WENHYATMSF EAEAQIVREL GKFLKEGSLY
190 200 210 220 230 240
RGFKPVLWST VEKTALADAE VEYQDHKSDT IYTAFPVKKT NIKELENTDV IIWTTTPWTI
250 260 270 280 290 300
PANKALAYNE ALDYLIIELG DEGDFKNKKI VVAEALLESV IKDCEIKSYK EIKKFKGKDF
310 320 330 340 350 360
KDTICSHPFL ELGYDYDIPM LEARFVTTEQ GTGIVHCAPS HGPDDFNLCL KYGIKAIETV
370 380 390 400 410 420
DGDGKYTKNL PLFEGTHIFK ANPIVIEKLK EQKKLLSNGE LVHSYPHSWR SKAPLVHRAT
430 440 450 460 470 480
PQWFISMESH GLRKKALKAL DDTKFYPDKG RERIKAMIET RPDWCVSRQR VWGVPLPIFV
490 500 510 520 530 540
HKTTKEILVD DNVNENIASI YEKEGSDCWF SDSPQRFLGD KYKAEDYEKI SDIVEVWFDS
550 560 570 580 590 600
GCTHAFVLEK REDLQWPASM YLEGSDQHRG WFHSSLLESC GTRGRAPYES ILSHGFVVDG
610 620 630 640 650 660
KGLKMSKSVG NVIAPEDILK KYGADILRIW VASSNYAEDL RIDYSILEQH ADSYRKIRNT
670 680 690 700 710 720
FRYLLGNLND DFQKIDLESL DIKQLPELER YMLHRVYELN NNFKNYFKSY DFHNLYKELL
730 740 750 760 770 780
NFCTVDLSSF YFDIRKDALY CDSKNSDRRK SSIVVLNIIL ESLVKWFAPI LSFTTEEIFT
790 800 810 820 830 840
LINKEQKSIH LEQFMKYPES FQDEELHKKW IELKKIRDIC NISIEAKRAS KEIGSSLEAS
850 860 870 880 890 900
LIINLNKSLF EISKNVDFSE ICITSSALVH QSNTDEIIIK TIKAEGNKCP VCWKINKVKC
ERHSD