Q4F883

PR
Gene name
SAG101 (At5g14930, F2G14.50)
Protein name
Senescence-associated carboxylesterase 101
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G14930
EC number
3.1.1.1: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

53-137 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q4F883

Entry ID Method Resolution Chain Position Source
4NFU X-ray 221 A B 2-537 PDB
7XJP EM 271 A B 1-537 PDB
AF-Q4F883-F1 Predicted AlphaFoldDB

52 variants for Q4F883

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06968600 39 N>Y No 1000Genomes
ENSVATH00622476 40 H>Q No 1000Genomes
ENSVATH06968601 42 P>L No 1000Genomes
ENSVATH06968602 50 K>R No 1000Genomes
tmp_5_4829065_G_A 54 G>S No 1000Genomes
tmp_5_4829066_G_T 54 G>V No 1000Genomes
ENSVATH08411726 61 R>P No 1000Genomes
ENSVATH08411726 61 R>Q No 1000Genomes
tmp_5_4829142_T_A 79 S>R No 1000Genomes
tmp_5_4829153_C_T 83 S>F No 1000Genomes
ENSVATH14032240 98 L>F No 1000Genomes
ENSVATH06968605 113 F>L No 1000Genomes
ENSVATH00622477 126 L>P No 1000Genomes
ENSVATH00622480 132 Q>H No 1000Genomes
tmp_5_4829567_A_G 138 K>E No 1000Genomes
tmp_5_4829570_C_T 139 P>S No 1000Genomes
ENSVATH06968610 166 T>M No 1000Genomes
ENSVATH06968611 169 R>C No 1000Genomes
tmp_5_4829661_G_A 169 R>H No 1000Genomes
tmp_5_4829692_G_T 179 L>F No 1000Genomes
ENSVATH06968612 181 G>A No 1000Genomes
tmp_5_4829762_T_C 203 S>P No 1000Genomes
ENSVATH06968613 208 I>T No 1000Genomes
tmp_5_4829810_T_A 219 F>I No 1000Genomes
tmp_5_4829832_G_A 226 G>E No 1000Genomes
ENSVATH06968614 243 V>I No 1000Genomes
tmp_5_4829952_C_T 266 A>V No 1000Genomes
ENSVATH14032241 269 R>T No 1000Genomes
tmp_5_4829975_G_A 274 D>N No 1000Genomes
ENSVATH14032242 278 G>* No 1000Genomes
ENSVATH06968615 279 I>M No 1000Genomes
tmp_5_4830003_C_T 283 A>V No 1000Genomes
ENSVATH00622485 313 K>T No 1000Genomes
tmp_5_4830113_G_T 320 G>C No 1000Genomes
tmp_5_4830144_C_T 330 A>V No 1000Genomes
ENSVATH03057298 346 S>A No 1000Genomes
tmp_5_4830321_A_G 389 D>G No 1000Genomes
ENSVATH03057299 397 G>R No 1000Genomes
ENSVATH03057300 404 T>R No 1000Genomes
ENSVATH14032243 405 G>V No 1000Genomes
ENSVATH00622487 407 S>P No 1000Genomes
ENSVATH00622488 411 V>I No 1000Genomes
ENSVATH06968621 426 K>T No 1000Genomes
tmp_5_4830443_A_G 430 K>E No 1000Genomes
tmp_5_4830473_T_A 440 F>I No 1000Genomes
ENSVATH06968622 455 I>M No 1000Genomes
ENSVATH03057301 483 V>M No 1000Genomes
tmp_5_4830695_A_G 514 K>E No 1000Genomes
tmp_5_4830702_T_A 516 F>Y No 1000Genomes
ENSVATH03057302 519 S>L No 1000Genomes
tmp_5_4830735_C_A 527 T>N No 1000Genomes
ENSVATH06968624 533 Y>N No 1000Genomes

No associated diseases with Q4F883

2 regional properties for Q4F883

Type Name Position InterPro Accession
domain Fungal lipase-like domain 113 - 203 IPR002921
domain EDS1, EP domain 305 - 518 IPR041266

Functions

Description
EC Number 3.1.1.1 Carboxylic ester hydrolases
Subcellular Localization
  • Membrane ; Single-pass membrane protein
  • Nucleus
  • Cytoplasm
  • Can move to the cytoplasm when in complex with PAD4 and EDS1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
EDS1 disease-resistance complex A plant complex involved in basal disease resistance and resistance (R) gene-mediated effector triggered immunity (ETI). Regulates accumulation of the hormone salicylic acid (SA) which is a necessary component of systemic immunity. Involved in responds to bacteria, viruses and oomycetes.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
carboxylic ester hydrolase activity Catalysis of the hydrolysis of a carboxylic ester bond.
methyl indole-3-acetate esterase activity Catalysis of the reaction: methyl indole-3-acetate + H2O = indole-3-acetate + methanol + H+.

10 GO annotations of biological process

Name Definition
aging A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
leaf abscission The controlled shedding of a leaf.
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
plant-type hypersensitive response The rapid, localized death of plant cells in response to invasion by a pathogen.
positive regulation of defense response to bacterium Any process that activates or increases the frequency, rate or extent of defense response to bacterium.
positive regulation of defense response to oomycetes Any process that activates or increases the frequency, rate or extent of defense response to oomycetes.
positive regulation of defense response to virus by host Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
positive regulation of leaf senescence Any process that activates or increases the frequency, rate or extent of leaf senescence.
systemic acquired resistance, salicylic acid mediated signaling pathway The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MESSSSLKGS ALGKLVVTSG LLHSSWSKIL EIHNPPYSNH DPGLQVSKKK KDSGLEFQIH
70 80 90 100 110 120
REEKFTLVVF SAPPICRSSS SDSTLLHVKD KENPFPFLCS ENNPSFSLHT PAFNLFTSAS
130 140 150 160 170 180
TSLTYLKSEL LQTLKSEKPV IITGAALGGS VASLYTLWLL ETIEPTLKRP LCITFGSPLI
190 200 210 220 230 240
GDASLQQILE NSVRNSCFLH VVSAQTRIKM DFFKPFGTFL ICFDSGCVCI EDHVAVTELL
250 260 270 280 290 300
NGVHDSGLVD YSQVLNRLDQ SMLSLADSRL IPEDVIKGIE KRAEMKNLRF DMMFKKLNDM
310 320 330 340 350 360
KISMAYIEWY KKKCKEVKIG YYDRFKTQLA FPSKEFDINI KNHHKSELNR FWKSVVEEVE
370 380 390 400 410 420
RRPQSDASIL KRRFLFSGNN YRRMIEPLDI AEYYLEGRKE YRTTGRSHHY VMLEKWFGME
430 440 450 460 470 480
SILIEKERCK KRDLSDLLTF DSCFWAEVED SLIVINQLNT TVGMRDDVRE VLTRKLVEFE
490 500 510 520 530
GYVWEIITKR EVSPEIFLEE SSFMKWWKEY KKIKGFNSSY LTEFMNTRKY ESYGKSQ