Q4AAX3
Gene name |
tyrS |
Protein name |
Tyrosine--tRNA ligase |
Names |
Tyrosyl-tRNA synthetase, TyrRS |
Species |
Mesomycoplasma hyopneumoniae (strain J / ATCC 25934 / NCTC 10110) (Mycoplasma hyopneumoniae) |
KEGG Pathway |
mhj:MHJ_0059 |
EC number |
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4AAX3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4AAX3-F1 | Predicted | AlphaFoldDB |
No variants for Q4AAX3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4AAX3 | |||||
No associated diseases with Q4AAX3
6 regional properties for Q4AAX3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Peptidase M41 | 563 - 744 | IPR000642 |
| domain | AAA+ ATPase domain | 341 - 480 | IPR003593 |
| domain | ATPase, AAA-type, core | 346 - 477 | IPR003959 |
| conserved_site | ATPase, AAA-type, conserved site | 448 - 466 | IPR003960 |
| domain | Peptidase M41, FtsH extracellular | 157 - 241 | IPR011546 |
| domain | AAA ATPase, AAA+ lid domain | 509 - 547 | IPR041569 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.1 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| tyrosine-tRNA ligase activity | Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tyrosyl-tRNA aminoacylation | The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSYIEKQEFL | TELKTRNILK | DISSPEKFFN | LKPDQGIYIG | FDPTATSLHL | GNYISISLLK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RLQKIGIKVL | AVIGGATGMI | GDPSFSSKER | KLLDFKTLNA | NKEKIKKQLE | SFGLPVFDNF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EIYKNMNILD | FLRDVGKNIN | ISYLLAKESV | ASRIEVGLSF | TEFSYQLIQG | WDFKFLAENY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QIIGQAGGSD | QWGNMVTGLD | FIKKSNLVQK | DEAFVFTTNL | LTDENGQKFG | KSLGKPIWLD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PEMYSPFHLY | QFLLNQNDEQ | AEKIMLWLSF | LDLKVINELI | FKHKNDKKQR | ILQYNLAQEV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VFNIHGDKGL | KIAKKITKIL | FEKLDYTEIT | FKDKLELKKI | IPYFKVSFFN | ANQIIDLGIF |
| 370 | 380 | 390 | 400 | 410 | |
| KSKRELNEFI | SHKALEINGS | KISNIGDITE | ELKDKSNLFL | LRKGKKYFFI | IELI |