Q4A633

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Mycoplasmopsis synoviae (strain 53) (Mycoplasma synoviae)
KEGG Pathway
msy:MS53_0376
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

392-468 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4A633

Entry ID Method Resolution Chain Position Source
AF-Q4A633-F1 Predicted AlphaFoldDB

No variants for Q4A633

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4A633

No associated diseases with Q4A633

4 regional properties for Q4A633

Type Name Position InterPro Accession
domain DHHA1 domain 756 - 872 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 650 - 693 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 548 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 706 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNSKEIRKAW LDFFESKNHF IVPPKSLIPV NDNSLLWINS GVATLKDYFS GKKNPPSKRM
70 80 90 100 110 120
ANSQKSIRTN DIENVGITAR HHTFFEMLGN FSIGGYFKKE AIEFATEFVL DVLKLDRSRL
130 140 150 160 170 180
YFTYFHDDLE TKNLWISQGF KEEQLIPGDR KTNFWEVGKG PCGPNTEIFY DRGEKYDQRG
190 200 210 220 230 240
IELLKNDIEN DRYIEIWNIV FSTYNSDGEG NYTELNQKNI DTGAGLERIV SILQDAPTNF
250 260 270 280 290 300
DTDLFLPIIH EIEKYTSYRY KIENYFIKDK AQKEINSYFK IIADHMRTVV NAIADGEKPS
310 320 330 340 350 360
NLSRGYILRR LIRRSYYKAI QLKITKSPFL YKLVDVIKAS LPFEYDSKKV AEVIKEEEVL
370 380 390 400 410 420
FSQTISKGKE ILEKFISENS SKDLFPGDLA YKLHETYGFP FELTEEILLQ KDIKINKEEF
430 440 450 460 470 480
NLAKEKHIEA SRNQKETGMD KVINSLALIK AKEDEFIGYE HTNSVSKILH LLNEENELSE
490 500 510 520 530 540
NDGTSYLILD KTPFYATSGG QKHDRGYIEQ NGVKLEILNV FKDKFGNHVH KVVGKLSKNY
550 560 570 580 590 600
PVTCQVDLKI RRGLERNHSG THLMFCALRN VFGNQIKQLG SDNNEDRLTF DAPFDSKPTN
610 620 630 640 650 660
EEILKVENLV KSYIQKEVDR QYLIMGIDQA KEINAIMTLE EAEYMDSSKL RIVNFNGITA
670 680 690 700 710 720
DLCGGTHLEN TKLLEDFKIT SVEKKAAGVY RIRAISSKET IEKYLENQKQ ELMQELLVLV
730 740 750 760 770 780
KKLKDMQFDF KVSLDESLEL SSQIQEIKNL TNLASEAIKN KIKENSKKIS IDLNEIELEN
790 800 810 820 830 840
INGNYLYLND EISKEEIKNL SGVIREKFPN ALVILISKGE AQSAISFASK KYNSINVLKE
850 860 870
LANHFELRGG GNAILAMGSI KDYSQLKTFL KEKYKWEN