Q49XV0

PR
Gene name
proC
Protein name
Pyrroline-5-carboxylate reductase
Names
P5C reductase, P5CR, PCA reductase
Species
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)
KEGG Pathway
ssp:SSP1250
EC number
1.5.1.2: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

185-268 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q49XV0

Entry ID Method Resolution Chain Position Source
AF-Q49XV0-F1 Predicted AlphaFoldDB

No variants for Q49XV0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q49XV0

No associated diseases with Q49XV0

2 regional properties for Q49XV0

Type Name Position InterPro Accession
domain Pyrroline-5-carboxylate reductase, catalytic, N-terminal 3 - 98 IPR028939
domain Pyrroline-5-carboxylate reductase, dimerisation domain 161 - 265 IPR029036

Functions

Description
EC Number 1.5.1.2 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
pyrroline-5-carboxylate reductase activity Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.

1 GO annotations of biological process

Name Definition
L-proline biosynthetic process The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLVFYGAGN MAHAIFTGIV NSKVIDSNDI YLTNRSNEVA LKEYAEKLGV NYSYDDEALL
70 80 90 100 110 120
KAADYVFLGT KPYDFESLAE RIKPFITDKN KFISIMAGLP ISYIREKLEA DNPIARIMPN
130 140 150 160 170 180
TNAHVGHSVT GISFSSNFGP NSKDEVDELI NAFGSAIEVP EDNLHQVTAI TGSGPAFLYH
190 200 210 220 230 240
VFEQYVTAGT RLGLEKAQVE ESIRNLIIGT SKMIERSELS MEQLRKNITS KGGTTQAGLN
250 260 270
ALSQHDLESV FEDCLRAAVD RSVELSSQDE D