Q49V12
Gene name |
mfd |
Protein name |
Transcription-repair-coupling factor |
Names |
TRCF |
Species |
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) |
KEGG Pathway |
ssp:SSP2253 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q49V12
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q49V12-F1 | Predicted | AlphaFoldDB |
No variants for Q49V12
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q49V12 | |||||
No associated diseases with Q49V12
6 regional properties for Q49V12
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal | 810 - 971 | IPR001650 |
| domain | CarD-like/TRCF, RNAP-interacting domain | 496 - 593 | IPR003711 |
| domain | Transcription-repair-coupling factor, C-terminal domain | 1022 - 1122 | IPR005118 |
| domain | DEAD/DEAH box helicase domain | 622 - 781 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 617 - 807 | IPR014001 |
| domain | UvrB, interaction domain | 139 - 227 | IPR041471 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| damaged DNA binding | Binding to damaged DNA. |
| helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| transcription-coupled nucleotide-excision repair, DNA damage recognition | The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKSIITEYIN | EDKRYQELNE | VFGKENVLVT | GLSGAAKATI | IAEKYLNSEQ | QLLVVTNNLY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QADKLESDLL | QFVEDSEIYK | YPMQDIMTEE | FSTQSPQFMS | ERVRTLTALA | QEERGLFIVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LNGLKKWLTP | VDMWKSHQLT | LNVGDDIDID | EFLNKLVNMG | YRRESVVSHI | GEFSLRGGIV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DIYPLIGKPV | RIEFFDTEVD | SIRDFDVESQ | RSEGNIEHVD | ITTASDYIIT | EDVLKHTKHK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LKQAYEDTRP | KIEKSVRNEL | KETYESFQLF | EAEMFDHQVL | RRLVAFMYEQ | PATIMDYFKE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DAIIAVDEYN | RIKETETTLV | TEIDEFMQNL | IESGKGFIDQ | SFLQYEGFEN | LLKPFAVTYF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLFTATMPVQ | LNEIIKFSCK | PVQQFYGQYD | IMRSEFQRFI | QNDYTIVVLA | ETETKKERIQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SMLNEMHIPT | FIDTPSRRNE | GGSAIITEGS | LSEGFELPYM | QLVVVTEREL | FKSKQKKKPK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QHKTLTNAEK | IKSYQDLKVG | DYVVHVHHGV | GRYLGVETLE | VGGVHKDYIK | LQYKGTDQLF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VPVDQMDQVQ | KYVASEDKSP | KLNKLGGTEW | KKTKAKVQQS | VEDMADELIE | LYKAREMSVG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YKFGPDTAEQ | NDFEIDFPYE | LTPDQSKSIE | EIKQDMEIER | PMDRLLCGDV | GYGKTEVAVR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AAFKAVMEGK | QVAFLVPTTI | LAQQHYETLI | ERMQDFPIEV | QLISRFRTTK | EVKETKEGLK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SGFVDIVVGT | HKLLGKDIQY | KDLGLLIVDE | EQRFGVRHKE | RIKSLKNNVD | VLTLTATPIP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RTLHMSMLGV | RDLSVIETPP | ENRFPVQTYV | LEQNTNFIKE | ALERELSRDG | QVFYLYNKVQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SIYEKREQLQ | MLMPDANIGV | AHGQMNERDL | EETMLSFINH | EYDIIVTTTI | IETGVDVPNA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NTLIIEDADR | FGLSQLYQLR | GRVGRSSRIG | YAYFLHPTNK | VLSETAEDRL | QAIKEFTELG |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SGFKIAMRDL | NIRGAGNLLG | KQQHGFIDSV | GFDLYSQMLE | EAVNEKRGIK | AEKQDAPEIE |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| IELNIDAYLP | AEYIPNEQSK | IEIYKKLRKI | ESETQLMDVK | DELIDRFNDY | PIEVERLLEM |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| MEIKVHALHA | GVTLIKDVGK | QVEVYLSEKG | TTDINGETLF | KQTQPLGRTM | KVGVQEGKMK |
| 1150 | 1160 | ||||
| VTLNKTGNWL | DSLKFLTKSL | EESMVITDEI |