Q49UL7

PR
Gene name
cysH
Protein name
Adenosine 5'-phosphosulfate reductase
Names
APS reductase, 5'-adenylylsulfate reductase, Thioredoxin-dependent 5'-adenylylsulfate reductase
Species
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)
KEGG Pathway
ssp:SSP2409
EC number
1.8.4.10: With a disulfide as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

192-242 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q49UL7

Entry ID Method Resolution Chain Position Source
AF-Q49UL7-F1 Predicted AlphaFoldDB

No variants for Q49UL7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q49UL7

No associated diseases with Q49UL7

1 regional properties for Q49UL7

Type Name Position InterPro Accession
domain Phosphoadenosine phosphosulphate reductase 43 - 214 IPR002500

Functions

Description
EC Number 1.8.4.10 With a disulfide as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
adenylyl-sulfate reductase (thioredoxin) activity Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin.
metal ion binding Binding to a metal ion.
phosphoadenylyl-sulfate reductase (thioredoxin) activity Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS.

1 GO annotations of biological process

Name Definition
sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSETKITYDD FNPHAFETLD ITDETKGARE VIRWAYDVYG DSIIYSCSFG AEGMILIDLI
70 80 90 100 110 120
SSVKKDAEIV FLDTNLHFQE TYDLIDRVKA RYPELNIKLK QPSLTLEEQA DQVAPALWKQ
130 140 150 160 170 180
DPNQCCYIRK IKPLEEVLSG ATAWVSGLRR EQSPSRQATN FINKDERFKS VKVCPLIHWT
190 200 210 220 230 240
WDDVWDYIKA HDLHYNELHD FNFPSIGCIP CTEAVSGNGD SRAGRWTNST KTECGLHTTN
KP