Q49SP5

PR
Gene name
Protein name
Germacrene A synthase
Names
PatTpsCF2
Species
Pogostemon cablin (Patchouli) (Mentha cablin)
KEGG Pathway
EC number
4.2.3.23: Acting on phosphates
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

151-222 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q49SP5

Entry ID Method Resolution Chain Position Source
AF-Q49SP5-F1 Predicted AlphaFoldDB

No variants for Q49SP5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q49SP5

No associated diseases with Q49SP5

3 regional properties for Q49SP5

Type Name Position InterPro Accession
domain Terpene synthase, N-terminal domain 22 - 200 IPR001906
domain Terpene synthase, metal-binding domain 231 - 495 IPR005630
domain Terpene cyclase-like 1, C-terminal domain 226 - 553 IPR034741

Functions

Description
EC Number 4.2.3.23 Acting on phosphates
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
germacrene-A synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate.
magnesium ion binding Binding to a magnesium (Mg) ion.
sesquiterpene synthase activity Catalysis of the reaction: trans,trans-farnesyl diphosphate = a sesquiterpene + diphosphate. Sesquiterpenes are terpenes containing three isoprene units, i.e. 15 carbons.

3 GO annotations of biological process

Name Definition
diterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units.
farnesyl diphosphate metabolic process The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation.
sesquiterpene biosynthetic process The chemical reactions and pathways resulting in the formation of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVQISETVR PFANFSPNPS LWGDQFINHK SKTQQISRIY LEEIEGLKNE VKCMLTSTPE
70 80 90 100 110 120
GKMADTVNLI DTLERLGVSY HFEKEIEEKM KHLFNLIKAD NYKDHEGCDL YTDALHFRLF
130 140 150 160 170 180
RQHGYPISSG IFNKWMDGNG KFKESIKSDA KGLLSLYEAC CLRTHGDTLL DEALVFATAS
190 200 210 220 230 240
LKSMAANLAS PLRKQVEHAL FQHLHFGIPR VEARHFITFY EEEEHKNEML LRFAKLDFNA
250 260 270 280 290 300
LQALHKEELS EISKWWKDLD LISKLPYARD RVVESYFWAV GVYYQPKYSR ARIMLTKTIA
310 320 330 340 350 360
MTAILDDTYD SYGTLEELDV LTKAIERWDI KEINGLPEYI KGFYKQVLKL YQQLEEELAK
370 380 390 400 410 420
EGRSYAVYYA IEACKELARS YAVEAKWFKK GYLPGFEEYL INSLVTSTAG YLNIISFFGV
430 440 450 460 470 480
ESVTKEDFEW FSKKPRIAVA TQIITRVIDD IATYEVEKEK GQSATGIDCY MKEHGVSKEK
490 500 510 520 530 540
AMQRFYEMST NAWKDINEEG LSWPSSFSRD IFVQLRNFSR MVDVTYGKNE DGYSKPEKIL
550
KPLIIALFVD QIKL