Q49GP3

PR
Gene name
pi4kb (pik4cb)
Protein name
Phosphatidylinositol 4-kinase beta
Names
PI4K-beta, PI4Kbeta, PtdIns 4-kinase beta
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:563201
EC number
2.7.1.67: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-173 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

708-730 (Activation loop from InterPro)

Target domain

548-835 (Catalytic domain of Type III Phosphoinositide 4-kinase beta)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q49GP3

Entry ID Method Resolution Chain Position Source
AF-Q49GP3-F1 Predicted AlphaFoldDB

No variants for Q49GP3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q49GP3

No associated diseases with Q49GP3

4 regional properties for Q49GP3

Type Name Position InterPro Accession
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 554 - 833 IPR000403
domain Phosphoinositide 3-kinase, accessory (PIK) domain 59 - 262 IPR001263
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 582 - 596 IPR018936-1
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 675 - 695 IPR018936-2

Functions

Description
EC Number 2.7.1.67 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Endomembrane system
  • Mitochondrion outer membrane ; Peripheral membrane protein
  • Rough endoplasmic reticulum membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
rough endoplasmic reticulum membrane The lipid bilayer surrounding the rough endoplasmic reticulum.

3 GO annotations of molecular function

Name Definition
1-phosphatidylinositol 4-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate.

4 GO annotations of biological process

Name Definition
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
semicircular canal development The progression of the semicircular canal from its initial formation to the mature structure.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39104 PIK1 Phosphatidylinositol 4-kinase PIK1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O02810 PI4KB Phosphatidylinositol 4-kinase beta Bos taurus (Bovine) PR
Q9UBF8 PI4KB Phosphatidylinositol 4-kinase beta Homo sapiens (Human) PR
Q8BKC8 Pi4kb Phosphatidylinositol 4-kinase beta Mus musculus (Mouse) PR
O08561 Pi4kb Phosphatidylinositol 4-kinase beta Rattus norvegicus (Rat) PR
A4IID4 pi4kb Phosphatidylinositol 4-kinase beta Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MGDTELELSP THLEELQKSP STSTTSSLSL PSSPSSGPHP LTSSSPSTSE GLPTSSPPLD
70 80 90 100 110 120
VISEGLGELS LVIDTEVAKK ACQEVLQKVK FLKGDGEVSS ASSEPILANG TAHPEANDGG
130 140 150 160 170 180
QPPKISEEEV EPIKSVRRRQ KNNSSKQSWL LRLFESKLFD ISMAISYLYN SKEPGVQAYI
190 200 210 220 230 240
GNRLFSFRNE DVDFYLPQLL NMYIHMDEDV GDAIKPYVVY RCRQSINFSL QCAWLLGAYS
250 260 270 280 290 300
SDMHISTQRH SRGTKLRKLI LSDELKPSSQ RIRREVPQPP PPYPPPLHHG PGMSEHSLSP
310 320 330 340 350 360
SKRTHQRSKS DATVSISLSS NLKRTASNPK VETSQDEPVR LTPQREFIKS LMGIGKRLAT
370 380 390 400 410 420
LPTKEQKTQR LISELSLLNH KLPARVWLPT AAFDHHVVRV PHTQAVVLNS KDKAPYLIYV
430 440 450 460 470 480
EVLECENFET SSVPVRIPET QIRSTRSVEN LPDCGITPDQ RASSFSTVPN YDNDDEAWSV
490 500 510 520 530 540
DDIGELQVEL PEIHTNSCDN ISQFSVDSIT SQESKEPIFI AAGDIRRRLS EQLAHTPTTF
550 560 570 580 590 600
RKDPEDPSAV ALKEPWQEKV RRIREGSPYG HLPNWRLLSV IVKCGDDLRQ ELLAYQVLKQ
610 620 630 640 650 660
LQIIWEQERV PLWIKPYKIL VISSDSGMIE PVVNAVSIHQ VKKQSQLLLL DYFRQEHGNF
670 680 690 700 710 720
NTEEFLTAQR NFVQSCAGYC LICYLLQVKD RHNGNILLDS EGHIIHIDFG FILSSSPRNL
730 740 750 760 770 780
GFETSAFKLT SEFVDVMGGL DGDMFNYYKM LMLQGLIAAR KHMEKVIQIV EIMQQGSQLP
790 800 810 820 830
CFHGSSTIRN LKERFHMNLT EEQLQVLVEQ MVDGSMRSIT TKLYDGFQYL TNGIM