Q49640

PR
Gene name
relA (ML0491, B1177_C1_168, MLCB1259.09)
Protein name
Probable GTP pyrophosphokinase
Names
(p)ppGpp synthase, ATP:GTP 3'-pyrophosphotransferase, ppGpp synthase I
Species
Mycobacterium leprae (strain TN)
KEGG Pathway
mle:ML0491
EC number
2.7.6.5: Diphosphotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-79 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q49640

Entry ID Method Resolution Chain Position Source
AF-Q49640-F1 Predicted AlphaFoldDB

No variants for Q49640

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q49640

No associated diseases with Q49640

7 regional properties for Q49640

Type Name Position InterPro Accession
domain ACT domain 706 - 785 IPR002912
domain HD/PDEase domain 98 - 221 IPR003607
domain TGS 447 - 508 IPR004095
domain HD domain 102 - 199 IPR006674
domain RelA/SpoT 273 - 400 IPR007685
domain RelA/SpoT, TGS domain 450 - 508 IPR033655
domain RelA/SpoT, AH and RIS domains 522 - 694 IPR045600

Functions

Description
EC Number 2.7.6.5 Diphosphotransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTP binding Binding to GTP, guanosine triphosphate.
GTP diphosphokinase activity Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

2 GO annotations of biological process

Name Definition
guanosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADDQGTAQA LQPVQVVPGP AVEAPETPVE TLKTSSSASR RVRARLARRM TAQRSTISPV
70 80 90 100 110 120
LEPLVAVHKE FYPKANLSIV QRAFEVADQR HASQLRRSGD PYITHPLAVA NILAELGMDI
130 140 150 160 170 180
TTLVAALLHD TVEDTGYTLE ALSEEFGDEV GHLVDGVTKL DRVVLGSAAE GETIRKMITA
190 200 210 220 230 240
MARDPRVLVI KVADRLHNMR TMRFLPPEKQ ARKARETLEV IAPLAHRLGM ASVKWELEDL
250 260 270 280 290 300
SFAILHPKKY EEIVRLVAGR APSRDTYLAK VRAEIISTLG ASKIKATVEG RPKHYWSIYQ
310 320 330 340 350 360
KMIVKGRDFD DIHDLVGIRI LCDEIRDCYA AVGVVHSLWQ PMAGRFKDYI AQPRYGVYQS
370 380 390 400 410 420
LHTTVVGPEG KPLEVQIRTR DMHRTAEYGI AAHWRYKEAK GRNGVLHPHA AAEIDDMAWM
430 440 450 460 470 480
RQLLDWQREA AEPGEFLESL RYDLAVQEIF VFTPKGDVIT LPTGSTPVDF AYAVHTEVGH
490 500 510 520 530 540
RCIGARVNGR LVALERKLEN GEFVEIFTSK APNAGPSRDW QQFVVSPRAK TKIRQWFAKE
550 560 570 580 590 600
RREEALEAGK DAMAREVRRG GLPLQRLVNG ESMAAVAREL HYIDVSALYT AIGEGHVSAR
610 620 630 640 650 660
HVVQRLLAEL GGIDQAEEEL AERSTPTTML RRQRSTDDVG VSVPGAPGVL TKLAKCCTPV
670 680 690 700 710 720
PGDAIMGFVT RGGGVSVHRT DCTNTASLQQ QAERIIEVLW APSSSSVFLV AIQVEALDRH
730 740 750 760 770 780
RLLLDITRAL ADERVDILSA SVTTSGDRVA ISRFTFEMGD PKHLGHLLNV VRNVEGVYDV
YRVMSAS