AiPD: Autoinhibited Protein Database

Q495A1

Gene name	TIGIT (VSIG9, VSTM3)
Protein name	T-cell immunoreceptor with Ig and ITIM domains
Names	V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:201633
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

147-240 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

147-240 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

8 structures for Q495A1

Entry ID	Method	Resolution	Chain	Position	Source
3Q0H	X-ray	170 A	A/B	22-137	PDB
3RQ3	X-ray	270 A	A/B	22-137	PDB
3UCR	X-ray	263 A	A/B/C/D	23-128	PDB
3UDW	X-ray	290 A	A/B	20-128	PDB
5V52	X-ray	310 A	A/B	22-128	PDB
7VYT	X-ray	153 A	A/T	23-129	PDB
8SZY	X-ray	231 A	T/U	23-128	PDB
AF-Q495A1-F1	Predicted				AlphaFoldDB

223 variants for Q495A1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA81660403 rs977245811	2	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs138322602 CA2550937	2	R>H	Variant assessed as Somatic; 5.895e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs138322602 CA354001981	2	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs138322602 CA354001985	2	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA354001970 rs977245811 COSM3426906	2	R>S	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA81660408 rs938517138	3	W>*		No	ClinGen gnomAD
rs1421141599 CA354002017	3	W>G		No	ClinGen gnomAD
CA354002011 rs1421141599	3	W>R		No	ClinGen gnomAD
CA354002043 rs1360039945	4	C>G		No	ClinGen gnomAD
rs1425212224 CA354002047	4	C>Y		No	ClinGen gnomAD
TCGA novel	5	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1363645948 CA354002078	5	L>P		No	ClinGen TOPMed gnomAD
rs1363645948 CA354002077	5	L>R		No	ClinGen TOPMed gnomAD
CA354002104 rs1435416102	7	L>P		No	ClinGen gnomAD
rs149574739 CA354002107	8	I>F		No	ClinGen ESP gnomAD
CA81660417 rs149574739	8	I>V		No	ClinGen ESP gnomAD
rs1221754538 CA354002132	9	W>R		No	ClinGen gnomAD
CA354002162 rs1161667590	10	A>D		No	ClinGen TOPMed
CA81660425 rs894398089	11	Q>P		No	ClinGen gnomAD
rs1037690852 CA81660457	14	R>K		No	ClinGen TOPMed gnomAD
rs771830740 CA2550941	14	R>S		No	ClinGen ExAC gnomAD
rs1481730480 CA354002299	15	Q>P		No	ClinGen gnomAD
rs1481730480 CA354002307	15	Q>R		No	ClinGen gnomAD
rs777596601 CA2550942	16	A>P		No	ClinGen ExAC TOPMed gnomAD
CA2550943 rs777596601	16	A>S		No	ClinGen ExAC TOPMed gnomAD
CA81660481 rs897902406	17	P>H		No	ClinGen Ensembl
CA354002376 rs1576134457	18	L>P		No	ClinGen Ensembl
rs377262337 CA2550946	19	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1467777402 CA354003425	23	M>L		No	ClinGen TOPMed
rs1169726816 CA354003455	25	G>D		No	ClinGen gnomAD
CA2550967 rs768453703	27	I>M		No	ClinGen ExAC gnomAD
rs749016800 CA2550966	27	I>T		No	ClinGen ExAC gnomAD
CA2550965 rs775439016	27	I>V		No	ClinGen ExAC TOPMed gnomAD
CA2550969 rs376892258	30	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2550968 COSM1229291 rs376892258	30	T>M	Variant assessed as Somatic; 0.0 impact. pancreas large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs759559781 CA2550972	31	G>E		No	ClinGen ExAC gnomAD
CA354003526 rs776752435	31	G>R		No	ClinGen ExAC gnomAD
CA2550971 rs776752435	31	G>W		No	ClinGen ExAC gnomAD
TCGA novel	32	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA354003533 rs1324498331	32	N>T		No	ClinGen gnomAD
rs200039145 CA2550974	33	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs13098836 CA2550973 VAR_056079	33	I>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
COSM445338 CA354003551 rs1441981882	34	S>F	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA354003557 rs1193996002	35	A>S		No	ClinGen gnomAD
rs142063959 COSM460948 CA2550975	36	E>K	cervix Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs752473184 CA81661749	38	G>D		No	ClinGen Ensembl
CA81661755 rs752473184	38	G>V		No	ClinGen Ensembl
rs1428691057 CA354003648	39	G>D		No	ClinGen TOPMed
rs1474404755 CA354003661	40	S>F		No	ClinGen gnomAD
TCGA novel	40	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA354003671 rs1192629675	41	I>V		No	ClinGen gnomAD
rs1429798923 CA354003729	43	L>F		No	ClinGen gnomAD
TCGA novel	43	L>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA354003732 rs1344755068	44	Q>K		No	ClinGen TOPMed
rs764546288 CA2550976	45	C>R		No	ClinGen ExAC gnomAD
rs756912053 CA354003789	46	H>Q		No	ClinGen ExAC gnomAD
CA354003778 rs1401063877	46	H>Y		No	ClinGen gnomAD
rs1319745958 CA354003802	47	L>F		No	ClinGen gnomAD
TCGA novel	47	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1267845 rs200389176 CA2550981	51	T>M	oesophagus stomach [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA354003889 rs1277935363	51	T>S		No	ClinGen gnomAD
CA2550983 rs373718714	52	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA354003988 rs1386709957	56	Q>*		No	ClinGen gnomAD
CA354004026 rs1286479882	57	V>F		No	ClinGen gnomAD
rs747946258 CA2550986	58	N>K		No	ClinGen ExAC gnomAD
rs1490761203 CA354004142	63	D>G		No	ClinGen gnomAD
CA2550989 rs759599957	65	L>P		No	ClinGen ExAC gnomAD
rs775775535 CA2550991	67	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1560031099 CA354004245	68	I>S		No	ClinGen Ensembl
rs1217152679 CA354004266	69	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA2550992 rs763518590	70	N>I		No	ClinGen ExAC gnomAD
rs751902028 CA2550994	71	A>D		No	ClinGen ExAC gnomAD
CA2550995 rs757591394	73	L>V		No	ClinGen ExAC TOPMed gnomAD
CA81661894 rs139315838	75	W>*		No	ClinGen ESP
rs202226565 CA2550996	75	W>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs750059977 CA2550997	76	H>N		No	ClinGen ExAC gnomAD
rs750059977 CA2550998	76	H>Y		No	ClinGen ExAC gnomAD
rs779535772 CA2550999	77	I>F		No	ClinGen ExAC gnomAD
rs779535772 CA354004556	77	I>L		No	ClinGen ExAC gnomAD
rs1330712252 CA354004649	80	S>P		No	ClinGen gnomAD
CA2551000 rs142612818	82	K>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1036624 CA2551001 rs754891716	84	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1351685650 CA354004787	84	R>P		No	ClinGen TOPMed gnomAD
CA354004784 COSM1417931 rs1351685650	84	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA2551002 rs778740978	85	V>G		No	ClinGen ExAC gnomAD
CA2551003 rs747938838	86	A>S		No	ClinGen ExAC gnomAD
rs1207805180 CA354004841	87	P>L		No	ClinGen TOPMed gnomAD
rs771774475 CA2551004	87	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1172005867 CA354004904	90	G>D		No	ClinGen TOPMed
CA2551005 rs777679603	90	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1560031155 CA354004925	91	L>P		No	ClinGen Ensembl
rs915945678 CA81661995	92	G>C		No	ClinGen TOPMed
rs770177197 CA2551007	94	T>I		No	ClinGen ExAC gnomAD
rs539986801 CA2551008	95	L>F		No	ClinGen ExAC TOPMed gnomAD
rs763148240 CA2551009	95	L>R		No	ClinGen ExAC gnomAD
rs554420760 CA2551010	96	Q>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA2551011 rs376092576	97	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA81662066 rs376092576	97	S>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1374976236 CA354005164	99	T>I		No	ClinGen gnomAD
CA354005162 rs1374976236	99	T>N		No	ClinGen gnomAD
rs207463547 CA2551013	100	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1294185632 CA354005209	101	N>H		No	ClinGen TOPMed
rs1361462365 CA354005214	101	N>S		No	ClinGen gnomAD
COSM296339 rs146935299 CA2551015	102	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1339906231 CA354005314	105	E>A		No	ClinGen gnomAD
rs766072812 CA2551016	105	E>D		No	ClinGen ExAC TOPMed gnomAD
rs779700793 CA354005330	106	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs779700793 CA2551018	106	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs1348411395 CA354005373	107	F>C		No	ClinGen Ensembl
CA354005390 rs1299695437	108	C>Y		No	ClinGen TOPMed
rs752561004 CA354005520	111	H>Q		No	ClinGen ExAC gnomAD
TCGA novel	111	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	114	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs559114697 CA2551021	114	P>T		No	ClinGen 1000Genomes ExAC gnomAD
rs201219748 CA2551022	117	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1165250020 CA354005764	119	T>N		No	ClinGen TOPMed
rs1398330159 CA354005999	128	E>G		No	ClinGen gnomAD
TCGA novel	128	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1576135716 CA354005962	128	E>Q		No	ClinGen Ensembl
rs201068475 CA2551026	129	S>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs201068475 CA354006028	129	S>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	130	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA81664812 rs966813707	133	E>K		No	ClinGen TOPMed gnomAD
CA2551046 rs778828718	134	H>Q		No	ClinGen ExAC gnomAD
CA354008169 rs1231845530	134	H>R		No	ClinGen gnomAD
rs868139905 CA81664817	134	H>Y		No	ClinGen gnomAD
CA2551047 rs147774909	135	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA354008225 rs1442193093	137	R>M		No	ClinGen TOPMed
rs1219504964 CA354008227 CA354008226	137	R>S		No	ClinGen TOPMed gnomAD
CA2551049 rs375103800	139	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2551050 CA2551051 rs149263615	139	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1195585172 CA354008328	140	I>L		No	ClinGen TOPMed
CA354008376 rs1360621086	141	P>S		No	ClinGen TOPMed
COSM1535860 CA81664846 rs201218843	145	A>D	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs201218843 CA2551052	145	A>V		No	ClinGen ExAC gnomAD
CA2551053 rs759155389	147	A>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA81664859 rs759155389	147	A>V		No	ClinGen ExAC gnomAD
rs369133784 CA2551055	148	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
COSM1036626 CA2551056 rs762554753	148	A>V	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs141092303 CA2551058	149	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA2551060 rs767417384	153	I>V		No	ClinGen ExAC gnomAD
CA354008836 rs1218334207	155	T>I		No	ClinGen gnomAD
CA354008885 rs1307066296	157	V>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA81664896 rs973073725	158	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs143771376 CA354008951	159	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2551062 rs143771376	159	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2551064 rs779221087	160	V>M		No	ClinGen ExAC
CA2551066 rs147577671	162	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs778198855 CA2551067	162	A>V		No	ClinGen ExAC gnomAD
rs148148852 CA2551069	164	T>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1441561287 CA354009038	165	R>G		No	ClinGen gnomAD
CA2551070 rs776955721	166	K>N		No	ClinGen ExAC TOPMed gnomAD
CA354011935 rs1223552727	167	K>R		No	ClinGen TOPMed
rs1286412108 CA354012055	171	R>I		No	ClinGen gnomAD
rs761432495 CA2551096	173	H>Y		No	ClinGen ExAC gnomAD
rs951616208 CA81669748	174	S>Y		No	ClinGen TOPMed
rs538730611 CA2551097	180	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773208493 CA2551098	181	R>K		No	ClinGen ExAC gnomAD
rs545231937 CA2551099	183	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs371034512 CA2551100	184	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	184	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	185	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2551101 rs753612238	186	Q>R		No	ClinGen ExAC
rs1212349351 CA354012511	187	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA81669760 rs868291940	189	W>*		No	ClinGen gnomAD
rs964918077 CA81669764	190	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA2551102 rs763135636	190	S>R		No	ClinGen ExAC gnomAD
CA2551103 rs764320930	192	S>G		No	ClinGen ExAC gnomAD
CA2551104 rs751596536	193	A>S		No	ClinGen ExAC gnomAD
rs1337670342 CA354012749	193	A>V		No	ClinGen TOPMed
rs757332270 CA2551105	194	P>L		No	ClinGen ExAC gnomAD
CA2551107 rs750928047	196	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs200210113 CA81669787	196	P>S		No	ClinGen TOPMed gnomAD
rs1357508515 CA354012840	197	P>A		No	ClinGen TOPMed
TCGA novel	197	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756645505 CA2551108	197	P>R		No	ClinGen ExAC gnomAD
TCGA novel	198	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA81669794 rs1022524945	199	S>G		No	ClinGen Ensembl
CA2551109 rs780435762	200	C>S		No	ClinGen ExAC gnomAD
CA81669799 rs968341813	202	Q>H		No	ClinGen TOPMed gnomAD
CA354013093 rs1441745465	204	E>D		No	ClinGen TOPMed gnomAD
CA2551111 rs749664204	204	E>G		No	ClinGen ExAC gnomAD
TCGA novel	204	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA354013087 rs749664204	204	E>V		No	ClinGen ExAC gnomAD
rs978431380 CA81669808	207	P>L		No	ClinGen TOPMed
rs978431380 CA354013180	207	P>R		No	ClinGen TOPMed
rs1190318925 CA354013177	207	P>S		No	ClinGen TOPMed
CA2551113 rs778741859	208	A>T		No	ClinGen ExAC gnomAD
CA354013195 rs1246976269	208	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1203915180 CA354013249	209	G>A		No	ClinGen TOPMed
CA2551114 rs765962768	211	C>Y		No	ClinGen ExAC gnomAD
rs760660502 CA2551117	213	E>D		No	ClinGen ExAC gnomAD
TCGA novel	213	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2551116 rs772660560	213	E>Q		No	ClinGen ExAC gnomAD
CA2551119 rs776434009	215	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2551118 COSM1036628 rs770819863	215	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1210010014 CA354013482	216	G>A		No	ClinGen TOPMed
CA2551120 rs759355698	217	E>D		No	ClinGen ExAC gnomAD
CA354013586 rs1363016574	218	D>V		No	ClinGen TOPMed gnomAD
TCGA novel	218	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs955942430 CA354013619	219	C>F		No	ClinGen TOPMed gnomAD
rs764231299 CA2551121	219	C>R		No	ClinGen ExAC TOPMed gnomAD
rs955942430 CA81669853	219	C>S		No	ClinGen TOPMed gnomAD
rs762078396 CA2551123	221	E>K		No	ClinGen ExAC TOPMed gnomAD
CA354013694 rs948555166	222	L>M		No	ClinGen gnomAD
rs11715493 CA2551126	223	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs374056654 CA2551127	225	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1427516463 CA354013997	227	N>K		No	ClinGen TOPMed
rs148174381 CA2551128	227	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1215590712 CA354014013	228	V>I		No	ClinGen gnomAD
CA81669905 rs935162780	229	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA354014082 rs935162780	229	L>V		No	ClinGen TOPMed gnomAD
CA2551130 rs187488656	233	S>R		No	ClinGen 1000Genomes ExAC gnomAD
CA354014242 rs1183814921	235	G>D		No	ClinGen TOPMed
rs747792969 CA2551131	237	C>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	237	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1470144873 CA354014345	238	S>R		No	ClinGen gnomAD
rs758195616 CA81669928	241	T>A		No	ClinGen ExAC gnomAD
CA2551132 rs758195616	241	T>P		No	ClinGen ExAC gnomAD
TCGA novel	242	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746519400 CA2551134	242	E>D		No	ClinGen ExAC gnomAD
rs142017149 CA2551135	244	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs891010005 CA81669958	245	G>W		No	ClinGen TOPMed

No associated diseases with Q495A1

3 regional properties for Q495A1

Type	Name	Position	InterPro Accession
domain	Immunoglobulin subtype	30 - 127	IPR003599
domain	Immunoglobulin-like domain	17 - 108	IPR007110
domain	Immunoglobulin V-set domain	31 - 126	IPR013106

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cell surface	The external part of the cell wall and/or plasma membrane.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

3 GO annotations of biological process

Name	Definition
negative regulation of interleukin-12 production	Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.
negative regulation of T cell activation	Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.
positive regulation of interleukin-10 production	Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MRWCLLLIWA	QGLRQAPLAS	GMMTGTIETT	GNISAEKGGS	IILQCHLSST	TAQVTQVNWE
70	80	90	100	110	120
QQDQLLAICN	ADLGWHISPS	FKDRVAPGPG	LGLTLQSLTV	NDTGEYFCIY	HTYPDGTYTG
130	140	150	160	170	180
RIFLEVLESS	VAEHGARFQI	PLLGAMAATL	VVICTAVIVV	VALTRKKKAL	RIHSVEGDLR
190	200	210	220	230	240
RKSAGQEEWS	PSAPSPPGSC	VQAEAAPAGL	CGEQRGEDCA	ELHDYFNVLS	YRSLGNCSFF

TETG