Q491V4

PR
Gene name
metE
Protein name
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Names
Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme
Species
Blochmannia pennsylvanicus (strain BPEN)
KEGG Pathway
bpn:BPEN_652
EC number
2.1.1.14: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

376-456 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q491V4

Entry ID Method Resolution Chain Position Source
AF-Q491V4-F1 Predicted AlphaFoldDB

No variants for Q491V4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q491V4

No associated diseases with Q491V4

2 regional properties for Q491V4

Type Name Position InterPro Accession
domain Cobalamin-independent methionine synthase MetE, C-terminal/archaeal 432 - 756 IPR002629
domain Cobalamin-independent methionine synthase MetE, N-terminal 6 - 311 IPR013215

Functions

Description
EC Number 2.1.1.14 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTIVGHILGF PRIGLHRELK YALEYYWDGK IKEDKLLEIG RTLRIRHWKQ QKDSGIDWIS
70 80 90 100 110 120
VGDFAWYDHV LTTSLMLNNI PDRHRIGQEN INLNTLFRIS RGYSLDKKLI PPSEMKKWFN
130 140 150 160 170 180
TNYHYIVPEF VPNQEFKLNW TQLFDEIDEA LSLKYTVKPI LLGPISYLWL GKIKGKKFDR
190 200 210 220 230 240
LSLLPNLLSV YQEILDILLS KNIDWIQIDE PILVLELPLQ WLNAYLSAYE QLHGKVKLLL
250 260 270 280 290 300
TTYFDSIYHQ LDIITRLKID GLHVDLVSNP DNIPLLHARL PKHWTLSAGV VNGRNVWKTN
310 320 330 340 350 360
LHDWFKKLYP LVGERSLWIG SSCSLLHSPI DLNTEIKLDK HIKEWFAFAL QKCYEIKMLC
370 380 390 400 410 420
AALNAENTSD ATYEDTLSEY YISNNLRSYS STIHNIQVKK RLEHIDEISY SRSSPYTTRV
430 440 450 460 470 480
TLQHKKLNLP LFPTTTIGSF PQTEEIRKLR SRFKNNQINK EDYHLNIKNY IKKIIMEQEK
490 500 510 520 530 540
LDLDILVHGE PERNDMVEYF GENLNGFIFT QNGWVQSYGS RCVKPPVIIG DISRSKPITI
550 560 570 580 590 600
EWISYAQSLT NKPIKGILTG PVTIMSWSFP REDMQRKTIA LQLALSIRDE VIDLEKSGIG
610 620 630 640 650 660
IIQIDEPALR EGLPLKRSDQ KQYLEWAINV FRITVSSVKD DTQIHTHMCY SEFSDIIYAI
670 680 690 700 710 720
LALDADVISI EAARSDEKIL KSIRHVIKNL NEIGPGIYDI HSPNKPTQND LIRRINQLLK
730 740 750 760
YIPEQRLWIN PDCGLKTRSW PEIKHSLNNM VSAAKLLRKQ FYSS