Q48R90

PR
Gene name
polC
Protein name
DNA polymerase III PolC-type
Names
PolIII
Species
Streptococcus pyogenes serotype M28 (strain MGAS6180)
KEGG Pathway
spb:M28_Spy1660
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

157-251 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q48R90

Entry ID Method Resolution Chain Position Source
AF-Q48R90-F1 Predicted AlphaFoldDB

No variants for Q48R90

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q48R90

No associated diseases with Q48R90

9 regional properties for Q48R90

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 341 - 408 IPR003141
domain PHP domain 342 - 700 IPR004013
domain DNA polymerase III epsilon subunit, exonuclease domain 422 - 642 IPR006054
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 842 - 1023 IPR011708-1
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 1039 - 1110 IPR011708-2
domain Exonuclease, RNase T/DNA polymerase III 426 - 592 IPR013520
domain DNA polymerase III PolC-like, N-terminal domain II 92 - 205 IPR024754
domain DNA polymerase III PolC-type, N-terminal domain I 5 - 78 IPR028112
domain DNA polymerase III alpha subunit finger domain 1114 - 1270 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

1 GO annotations of biological process

Name Definition
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDLFAKLMD QIEMPLDMRR SSAFSSADII EVKVHSVSRL WEFHFAFAAV LPIATYRELH
70 80 90 100 110 120
DRLIRTFEAA DIKVTFDIQA AQVDYSDDLL QAYYQEAFEH APCNSASFKS SFSKLKVTYE
130 140 150 160 170 180
DDKLIIAAPG FVNNDHFRNS HLPNLVKQFE AFGFGTLTID MVSDQEMTEH LTKDFVSSRQ
190 200 210 220 230 240
ALVKKAVQDN LEAQKSLEAM MPPVEEATPA PKFDYKERAA KRQAGFEKAT ITPMIEIETE
250 260 270 280 290 300
ENRIVFEGMV FDVERKTTRT GRHIINFKMT DYTSSFALQK WAKDDEELRK FDMIAKGAWL
310 320 330 340 350 360
RVQGNIETNP FTKSLTMNVQ QVKEIVHHDR KDLMPEGQKR VELHAHTNMS TMDALPTVES
370 380 390 400 410 420
LIDTAAKWGH KAVAITDHAN VQSFPHGYHR ARKAGIKAIF GLEANIVEDK VPISYDPVDM
430 440 450 460 470 480
DLHEATYVVF DVETTGLSAM NNDLIQIAAS KMFKGNIVEQ FDEFIDPGHP LSAFTTELTG
490 500 510 520 530 540
ITDKHLQDAK PLVTVLKAFQ DFCKDSILVA HNASFDVGFM NANYERHDLP KITQPVIDTL
550 560 570 580 590 600
EFARNLYPEY KRHGLGPLTK RFQVSLDHHH MANYDAEATG RLLFIFLRDA REKHGIKNLL
610 620 630 640 650 660
QLNTDLVAED SYKKARIKHA TIYVQNQVGL KNMFKLVSLS NIKYFEGVPR IPRTVLDAHR
670 680 690 700 710 720
EGLLLGTACS DGEVFDAVLT KGIDAAVDLA KYYDFIEIMP PAIYQPLVVR ELIKDQAGIE
730 740 750 760 770 780
QVIRDLIEVG KRANKPVLAT GNVHYLEPEE EIYREIIVRS LGQGAMINRT IGRGEGAQPA
790 800 810 820 830 840
PLPKAHFRTT NEMLDEFAFL GKDLAYQVVV ENTQDFADRI EEVEVVKGDL YTPYIDKAEE
850 860 870 880 890 900
TVAELTYQKA FEIYGNPLPD IIDLRIEKEL TSILGNGFAV IYLASQMLVN RSNERGYLVG
910 920 930 940 950 960
SRGSVGSSFV ATMIGITEVN PMPPHYVCPS CQHSEFITDG SVGSGYDLPN KPCPKCGTPY
970 980 990 1000 1010 1020
QKDGQDIPFE TFLGFDGDKV PDIDLNFSGD DQPSAHLDVR DIFGDEYAFR AGTVGTVAEK
1030 1040 1050 1060 1070 1080
TAYGFVKGYE RDYGKFYRDA EVDRLAAGAA GVKRTTGQHP GGIVVIPNYM DVYDFTPVQY
1090 1100 1110 1120 1130 1140
PADDVTASWQ TTHFNFHDID ENVLKLDILG HDDPTMIRKL QDLSGIDPIT IPADDPGVMA
1150 1160 1170 1180 1190 1200
LFSGTEILGV TPEQIGTPTG MLGIPEFGTN FVRGMVNETH PTTFAELLQL SGLSHGTDVW
1210 1220 1230 1240 1250 1260
LGNAQDLIKE GIATLKTVIG CRDDIMVYLM HAGLEPKMAF TIMERVRKGL WLKISEEERN
1270 1280 1290 1300 1310 1320
GYIDAMRENN VPDWYIESCG KIKYMFPKAH AAAYVLMALR VAYFKVHHPI MYYCAYFSIR
1330 1340 1350 1360 1370 1380
AKAFELKTMS GGLDAVKARM EDITIKRKNN EATNVENDLF TTLEIVNEML ERGFKFGKLD
1390 1400 1410 1420 1430 1440
LYKSDAIEFQ IKGDTLIPPF IALEGLGENV AKQIVKARQE GEFLSKMELR KRGGASSTLV
1450 1460
EKMDEMGILG NMPEDNQLSL FDDFF