Q48A12

PR
Gene name
trmA
Protein name
tRNA/tmRNA (uracil-C(5))-methyltransferase
Names
tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase
Species
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
KEGG Pathway
cps:CPS_0336
EC number
2.1.1.35: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q48A12

Entry ID Method Resolution Chain Position Source
AF-Q48A12-F1 Predicted AlphaFoldDB

No variants for Q48A12

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q48A12

No associated diseases with Q48A12

2 regional properties for Q48A12

Type Name Position InterPro Accession
active_site RNA methyltransferase TrmA, active site 297 - 326 IPR030390
conserved_site RNA methyltransferase TrmA, conserved site 346 - 356 IPR030391

Functions

Description
EC Number 2.1.1.35 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFSHIHPDNY DAQLSKKQQD MAKLFSDFNL PAPDLYPSVP LNYRQRAEFR VWHEGDDLYY
70 80 90 100 110 120
IMFDSKTKEK FRVDDFPVAS ELINNAMKAL LATIKDQREL RFKLFQVDFL STLSGELLIS
130 140 150 160 170 180
MLYHKPLEDN WQIEAEKLKA QLSTIAPVDI IGRAKKQKII VDKDYVMESL NVGGKTYVYQ
190 200 210 220 230 240
QVENSFTQPN AGVNEQMLLW AQQATQNAGG DLIELYCGNG NFSIALAENF ERVLGTEISK
250 260 270 280 290 300
TSVRSAQINI SENGIDNIDI VRMSSEEFSQ AMNGERKFRR LEDFDLTTYN YDTVLVDPPR
310 320 330 340 350 360
AGLDRDSVEL VRRFNKIIYI SCNPETLKDN LALLVETHQI DKFALFDQFP YTDHIETGVI
LTRK