Q48462

PR
Gene name
manC (cpsB)
Protein name
Mannose-1-phosphate guanylyltransferase
Names
GDP-mannose pyrophosphorylase, GMP, GMPP, ORF16
Species
Klebsiella pneumoniae
KEGG Pathway
EC number
2.7.7.13: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

312-386 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q48462

Entry ID Method Resolution Chain Position Source
AF-Q48462-F1 Predicted AlphaFoldDB

No variants for Q48462

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q48462

No associated diseases with Q48462

2 regional properties for Q48462

Type Name Position InterPro Accession
domain Mannose-6-phosphate isomerase, type II, C-terminal 316 - 466 IPR001538
domain Nucleotidyl transferase domain 4 - 288 IPR005835

Functions

Description
EC Number 2.7.7.13 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
mannose-1-phosphate guanylyltransferase activity Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose.

2 GO annotations of biological process

Name Definition
GDP-mannose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate.
lipopolysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLLPVIMAGG TGSRLWPMSR ELYPKQFLRL FGQNSMLQET ITRLSGLEIH EPMVICNEEH
70 80 90 100 110 120
RFLVAEQLRQ LNKLSNNIIL EPVGRNTAPA IALAALQATR HGDDPLMLVL AADHIINNQP
130 140 150 160 170 180
VFHDAIRVAE QYADEGHLVT FGIVPNAPET GYGYIQRGVA LTDSAHTPYQ VARFVEKPDR
190 200 210 220 230 240
ERAEAYLASG EYYWNSGMFM FRAKKYLSEL AKFRPDILEA CQAAVNAADN GSDFISIPHD
250 260 270 280 290 300
IFCECPDESV DYAVMEKTAD AVVVGLDADW SDVGSWSALW EVSPKDEQGN VLSGDAWVHN
310 320 330 340 350 360
SENCYINSDE KLVAAIGVEN LVIVSTKDAV LVMNRERSQD VKKAVEFLKQ NQRSEYKRHR
370 380 390 400 410 420
EIYRPWGRCD VVVQTPRFNV NRITVKPGGA FSMQMHHHRA EHWVILAGTG QVTVNGKQFL
430 440 450 460 470
LTENQSTFIP IGAEHSLENP GRIPLEVLEI QSGSYLGEDD IIRIKDQYGR C