Q47QV9

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Thermobifida fusca (strain YX)
KEGG Pathway
tfu:Tfu_1120
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

803-872 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q47QV9

Entry ID Method Resolution Chain Position Source
AF-Q47QV9-F1 Predicted AlphaFoldDB

No variants for Q47QV9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q47QV9

No associated diseases with Q47QV9

3 regional properties for Q47QV9

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class Ia 25 - 638 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 698 - 843 IPR013155
domain Isoleucyl tRNA synthetase type 2, anticodon-binding domain 652 - 830 IPR033709

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKESTRPFP TLPAQIDLPA MEHEVLRRWE EHKIFERSLE QTQGGPTWVF YEGPPTANGT
70 80 90 100 110 120
PGVHHVEARV FKDVFPRFKT MKGFYVERKA GWDCHGLPVE VAVEKELGIS GKKDIEAFGI
130 140 150 160 170 180
AEFNARCRES VLRNVDAFTE MTRRMGYWVN MDEAYRTMDR EYVESVWWAI KQIWDKGLLV
190 200 210 220 230 240
QDYRISPYCP RCGTTLSDHE LAQGYETVTD PSVYVRFPLT SGPLAGQAAL LVWTTTPWTL
250 260 270 280 290 300
VSNTAVAVHP EVDYVVATDG SEQLVVAEPL VGAALGDGWT LTGQRFKGAE LERWTYQRPF
310 320 330 340 350 360
ELVEFDSPAH FVVLGDYVTV EDGTGLVHQA PAFGADDMQV CRAYGLPVVN PVRNDGTFEE
370 380 390 400 410 420
HLDLVGDEFF KTADAALVAD LKDRGLLFKH LDYEHSYPHC WRCHTPLMYY AVPSWYIKTT
430 440 450 460 470 480
AIKDQLLAEN AKTNWVPANV KDGRYGEWLR NNVDWALSRS RYWGTPLPIW EFPDGRRICV
490 500 510 520 530 540
GSLKELSELS GQDLSDLDPH RPYVDDIVIP DPDADPSLPL EQRVARRVPE VIDVWFDSGA
550 560 570 580 590 600
MPFAQWGAPH RNQEKFEANF PAQYICEAID QTRGWFYSLM AVSTLVFGRS SYENVVCLGH
610 620 630 640 650 660
ILAEDGRKMS KHLGNILEPI PVMDRHGADA LRWFMAASGS PWMPRRVGHT VLEEIVRKVL
670 680 690 700 710 720
LTYYNSASFF TLYAGAGDGW SHEQLADAPA PQDRPLLDRW ILSELHSLIK TVDDALERFD
730 740 750 760 770 780
TALAGRALTT FIDDLSNWYV RRSRRRFWAG AGTPEGAAAF ATLFECLETL TLLMAPIVPF
790 800 810 820 830 840
ITDHVWQALR RPDAPESVHL ASWPKADESL IDPALSEQMA LVRRLVELGR AARVDSGQRV
850 860 870 880 890 900
RQPLARALVG APGFAELPEQ LRAQIAEELN VVQLDPLSVV GGDLVDYSVK PNFRALGKRF
910 920 930 940 950 960
GKTTPRVAQA IREADAKTLV ERLRADNAAT VDVDGEQVVL SADEVVVTEQ PREGWTVASE
970 980 990 1000 1010 1020
AGETVALDLE LTPELRRAGV AREVIRLVQD ARKSSGLNIS DRIHLWWSAT DEMTAQAMAE
1030 1040 1050
HAEAISSEVL AVSFTEGTGD ADAYEVVSEE FGITLRLRKA