Q47MY0

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Thermobifida fusca (strain YX)
KEGG Pathway
tfu:Tfu_2156
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q47MY0

Entry ID Method Resolution Chain Position Source
AF-Q47MY0-F1 Predicted AlphaFoldDB

No variants for Q47MY0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q47MY0

No associated diseases with Q47MY0

5 regional properties for Q47MY0

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 53 - 64 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 430 - 632 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 671 - 792 IPR013155
domain Methionyl/Leucyl tRNA synthetase 52 - 194 IPR015413
domain Leucyl-tRNA synthetase, editing domain 233 - 416 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTAVSGDQTT SGSYDVRALQ EKWQARWAKE NPFTASEDPA DPRPRRYVLD MFPYPSGDLH
70 80 90 100 110 120
MGHAEAFAIG DVIARYHFAR GENVLHPIGW DSFGLPAENA AIKHNFHPAE WTYTNIETQA
130 140 150 160 170 180
ESFRRYAISL DWSRRLHTSD PEYYRWNQWF FLRFFERGLA YRKDGLVNWC PKDQTVLANE
190 200 210 220 230 240
QVIQGKCERC GTEVERRALN QWYFKITDYA QRLLDDMEQL EGKWPERVLT MQRNWIGRSE
250 260 270 280 290 300
GADVQFTIEG REEPVTVFTT RPDTLYGATF FVVAPDSPLA DELCAPEQRE AFEAYRTQVS
310 320 330 340 350 360
KLSDIERQST EREKTGVFLG RYAINPVNGE RIPVWAADYV LADYGHGAIM AVPAHDQRDL
370 380 390 400 410 420
DFARKFNLPV RVVVDTGEPD PAETGIATPG EGTLINSGPL NGLSKSEAIP RIIEILTERG
430 440 450 460 470 480
TGKAAVNYRL RDWLVSRQRF WGTPIPIIHC PECGEVPVPD EELPVRLPDL RGAALAPKGV
490 500 510 520 530 540
SPLAAATDWV NVSCPRCGGP AKRDTDTMDT FVDSSWYFLR YCSPNLDTAP FDQEKVAKWG
550 560 570 580 590 600
PIDQYVGGVE HAILHLLYSR FFTKVLYDMG MVPFTEPFVR LLNQGQVINQ GKAMSKSLGN
610 620 630 640 650 660
GVDLGQEIDR YGVDAVRLTM VFAGPPEEDI DWADVSPGAS VKFLNRAYRV MAEAAAASAP
670 680 690 700 710 720
GVDPATGDLA LRRMTHQTLA KVTEAVEAQR FNVAIARIME LVTAARRAID SGPGAADPAV
730 740 750 760 770 780
REAAEVIAIT LGLFAPYVAE EGWEMLGHTG SVSVGTWREP DPALLVQESV TCVVQVASKV
790 800 810 820
RDKLQVSPDI SAEELERLAL ASEKVQNHIA GREIRRIVVR EPKLVNIVVA