Q47622

PR
Gene name
sapA (b1294, JW1287)
Protein name
Probable ABC transporter periplasmic-binding protein SapA
Names
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1294
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q47622

Entry ID Method Resolution Chain Position Source
AF-Q47622-F1 Predicted AlphaFoldDB

No variants for Q47622

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q47622

No associated diseases with Q47622

2 regional properties for Q47622

Type Name Position InterPro Accession
domain Solute-binding protein family 5 domain 79 - 457 IPR000914
conserved_site Solute-binding protein family 5, conserved site 84 - 106 IPR023765

Functions

Description
EC Number
Subcellular Localization
  • Periplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.

1 GO annotations of molecular function

Name Definition
peptide transmembrane transporter activity Enables the transfer of a peptide from one side of a membrane to the other.

1 GO annotations of biological process

Name Definition
peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P46890 ybaE Uncharacterized protein YbaE Escherichia coli (strain K12) PR
10 20 30 40 50 60
MRQVLSSLLV IAGLVSGQAI AAPESPPHAD IRDSGFVYCV SGQVNTFNPS KASSGLIVDT
70 80 90 100 110 120
LAAQFYDRLL DVDPYTYRLM PELAESWEVL DNGATYRFHL RRDVPFQKTD WFTPTRKMNA
130 140 150 160 170 180
DDVVFTFQRI FDRNNPWHNV NGSNFPYFDS LQFADNVKSV RKLDNHTVEF RLAQPDASFL
190 200 210 220 230 240
WHLATHYASV MSAEYARKLE KEDRQEQLDR QPVGTGPYQL SEYRAGQFIR LQRHDDFWRG
250 260 270 280 290 300
KPLMPQVVVD LGSGGTGRLS KLLTGECDVL AWPAASQLSI LRDDPRLRLT LRPGMNVAYL
310 320 330 340 350 360
AFNTAKPPLN NPAVRHALAL AINNQRLMQS IYYGTAETAA SILPRASWAY DNEAKITEYN
370 380 390 400 410 420
PAKSREQLKS LGLENLTLKL WVPTRSQAWN PSPLKTAELI QADMAQVGVK VVIVPVEGRF
430 440 450 460 470 480
QEARLMDMSH DLTLSGWATD SNDPDSFFRP LLSCAAIHSQ TNLAHWCDPK FDSVLRKALS
490 500 510 520 530 540
SQQLAARIEA YDEAQSILAQ ELPILPLASS LRLQAYRYDI KGLVLSPFGN ASFAGVYREK
QDEVKKP