Q474V6

PR
Gene name
argH
Protein name
Argininosuccinate lyase
Names
ASAL, Arginosuccinase
Species
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator (strain JMP 134))
KEGG Pathway
reu:Reut_A0695
EC number
4.3.2.1: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q474V6

Entry ID Method Resolution Chain Position Source
AF-Q474V6-F1 Predicted AlphaFoldDB

No variants for Q474V6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q474V6

No associated diseases with Q474V6

3 regional properties for Q474V6

Type Name Position InterPro Accession
conserved_site Fumarate lyase, conserved site 277 - 286 IPR020557
domain Fumarate lyase, N-terminal 8 - 302 IPR022761
domain Argininosuccinate lyase, C-terminal 365 - 432 IPR029419

Functions

Description
EC Number 4.3.2.1 Lyases acting on amides, amidines, etc
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.

1 GO annotations of biological process

Name Definition
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTSQLAKKG EAWSARFSEP MSDLVKRYTA SVFFDKRLAL FDIQGSLAHA AMLAKQGIIA
70 80 90 100 110 120
EADRAEIERG MAQIKGEIEA GGFEWKLDLE DVHLNIEARL TALVGDAGKR LHTGRSRNDQ
130 140 150 160 170 180
VATDIRLWLR SEIDNIIALL GALRGSLLDL ADQNADTILP GFTHLQVAQP VTFGHHLLAY
190 200 210 220 230 240
VEMFTRDAER MADCRKRVNR LPLGAAALAG TSYPIDREFV AQQLGFDGVC RNSLDAVSDR
250 260 270 280 290 300
DFAIEFCAAA ALVMTHVSRF SEELVLWMSP RVGFIDIADR FCTGSSIMPQ KKNPDVPELA
310 320 330 340 350 360
RGKTGRVNGH LIGLLTLMKG QPLAYNKDNQ EDKEPLFDTV DTVVDTLRIF ADMVPGITVK
370 380 390 400 410 420
PEAMRAAALQ GYATATDLAD YLVKKGLPFR DAHEAVAHAV RACDSRNCDL ADLTVAELRE
430 440 450 460
VSGLGDKSAL IGDDVHTVLT LEGSVAARNH IGGTAPDQVR AAIAAARAAL