Q472N4

PR
Gene name
pheS
Protein name
Phenylalanine--tRNA ligase alpha subunit
Names
Phenylalanyl-tRNA synthetase alpha subunit, PheRS
Species
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator (strain JMP 134))
KEGG Pathway
reu:Reut_A1279
EC number
6.1.1.20: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q472N4

Entry ID Method Resolution Chain Position Source
AF-Q472N4-F1 Predicted AlphaFoldDB

No variants for Q472N4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q472N4

No associated diseases with Q472N4

3 regional properties for Q472N4

Type Name Position InterPro Accession
domain Phenylalanyl-tRNA synthetase 104 - 353 IPR002319
domain Phenylalanine-tRNA ligase, class II, N-terminal 32 - 99 IPR004188
domain Aminoacyl-tRNA synthetase, class II 128 - 352 IPR006195

Functions

Description
EC Number 6.1.1.20 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phenylalanine-tRNA ligase activity Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSRRQAISTT AMSQDLDQIV ADAQAAFAAA NDNATLENEK ARFLGKTGAL TELLKGLGKL
70 80 90 100 110 120
DPETRKTEGA RINQVKQQVE AALTARRQAL ADALMNARLS AEAIDVTLPG RAVSRGSLHP
130 140 150 160 170 180
VMRTWERVEQ IFGSIGFDVA DGPEIETDWM NFTALNNPDN HPARSMQDTF YIDGRDSDDK
190 200 210 220 230 240
LLLLRTHTSP MQVRYAKMHV EKYAGKAMPP IKVICPGRTY RVDSDATHSP MFNQVEGLWI
250 260 270 280 290 300
GEDVSFADLK GVYTDFLRKF FERDDIQVRF RPSYFPFTEP SAEIDMAFGN GKWLEISGSG
310 320 330 340 350
QVHPNVLRNM GLDPERYIGF AFGSGLERLT MLRYGINDLR LFFEGDVRFL RQFA