Q47282

PR
Gene name
hsdM
Protein name
Type I restriction enzyme EcoEI methylase subunit
Names
M protein, Type I methyltransferase M.EcoEI, M.EcoEI
Species
Escherichia coli
KEGG Pathway
EC number
2.1.1.72: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

108-182 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q47282

Entry ID Method Resolution Chain Position Source
AF-Q47282-F1 Predicted AlphaFoldDB

No variants for Q47282

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q47282

No associated diseases with Q47282

3 regional properties for Q47282

Type Name Position InterPro Accession
conserved_site DNA methylase, N-6 adenine-specific, conserved site 270 - 276 IPR002052
domain DNA methylase, adenine-specific 140 - 452 IPR003356
domain N6 adenine-specific DNA methyltransferase, N-terminal domain 4 - 130 IPR022749

Functions

Description
EC Number 2.1.1.72 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
N-methyltransferase activity Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule.
site-specific DNA-methyltransferase (adenine-specific) activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

1 GO annotations of biological process

Name Definition
DNA restriction-modification system A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSISSVIKSL QDIMRKDAGV DGDAQRLGQL SWLLFLKIFD TQEEELELEQ DDYQFPIPQR
70 80 90 100 110 120
YLWRSWAANS EGITGDALLE FVNDDLFPTL KNLTAPIDKN PRGFVVKQAF SDAYNYMKNG
130 140 150 160 170 180
TLLRQVINKL NEIDFSSSQE RHLFGDIYEQ ILRDLQSAGN AGEFYTPRAV TRFMVNRIDP
190 200 210 220 230 240
KLGESIMDPA CGTGGFLACA FDHVKDNYVK TTEDHKTLQQ QIYGVEKKQL PHLLCTTNML
250 260 270 280 290 300
LHGIEVPVQI RHDNTLNKPL SSWDEQVDVI VTNPPFGGTE EDGIEKNFPA EMQTRETADL
310 320 330 340 350 360
FLQLIIEVLA DKGRAAVVLP DGTLFGEGVK TKIKKLLTEE CNLHTIVRLP NGVFNPYTGI
370 380 390 400 410 420
KTNILFFTKG QPTKEVWFYE HPYPDGVKNY SKTKPMKFEE FQAEIDWWGN EADDFASREE
430 440 450 460 470 480
NNQAWKVGID DIIARNFNLD IKNPYQGETI SHDPDELLAQ YQTQQAEIGE LRNQLRDILG
AALAGNKGAN