Q46ZI4

PR
Gene name
hisS
Protein name
Histidine--tRNA ligase
Names
Histidyl-tRNA synthetase, HisRS
Species
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator (strain JMP 134))
KEGG Pathway
reu:Reut_A2085
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q46ZI4

Entry ID Method Resolution Chain Position Source
AF-Q46ZI4-F1 Predicted AlphaFoldDB

No variants for Q46ZI4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q46ZI4

No associated diseases with Q46ZI4

3 regional properties for Q46ZI4

Type Name Position InterPro Accession
domain Anticodon-binding 331 - 417 IPR004154
domain Aminoacyl-tRNA synthetase, class II 1 - 324 IPR006195
domain Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain 8 - 317 IPR041715

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

1 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTQNENPSAQ SGAKPEDKAR PAKALQGVKG MNDMLPADAP LWEHFENAAR AMLRAYGYQQ
70 80 90 100 110 120
IRTPIVEHTQ LFVRGIGEVT DIVEKEMYSF TDALNGEQLT LRPEGTAAAV RATIEHNLLY
130 140 150 160 170 180
DGPKRLWYTG PMFRHERPQR GRYRQFHQLG AEALGFAGPD VDAEIILMCQ RLWDDLGLTG
190 200 210 220 230 240
VRLEINSLGQ AHERAAHREE LIKYLEGFKD ILDEDGKRRL YTNPLRVLDT KNPALQEMAA
250 260 270 280 290 300
NAPKLIDFLG EESLAHFEGV QRLLKANNIP YKINPRLVRG LDYYNLTVFE WITDKLGAQG
310 320 330 340 350 360
TIAGGGRYDP LIAQMGGKAA PACGWAMGIE RIIELIREEG VVPDAVGCDV YLVHQGEAAQ
370 380 390 400 410 420
QQATVAAERL RDAGLDVVLH ATPDGKSGSF KSQMKRADAS GAAYAVIIGE DEVAAGVVQV
430 440 450
KELRQGAQAE GGGQQAQVPA ENLVDYLIDA MVGASE