Q46XD8

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator (strain JMP 134))
KEGG Pathway
reu:Reut_A2834
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

582-672 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q46XD8

Entry ID Method Resolution Chain Position Source
AF-Q46XD8-F1 Predicted AlphaFoldDB

No variants for Q46XD8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q46XD8

No associated diseases with Q46XD8

6 regional properties for Q46XD8

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 48 - 59 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 433 - 588 IPR002300-1
domain Aminoacyl-tRNA synthetase, class Ia 635 - 675 IPR002300-2
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 714 - 835 IPR013155
domain Methionyl/Leucyl tRNA synthetase 44 - 177 IPR015413
domain Leucyl-tRNA synthetase, editing domain 226 - 418 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQDKYLPSAV EQAAQQHWQA IDAYRVPEHA TGPDGKEKPK FYACSMLPYP SGKLHMGHVR
70 80 90 100 110 120
NYTINDVMAR YLRMNGNNVL MPMGWDAFGM PAENAALNNG VAPAAWTYDN IAYMKKQMQS
130 140 150 160 170 180
MGLAIDWSRE VATCSPDYYR WNQWLFLKML EKGIAYRKTG TVNWDPVDQT VLANEQVIDG
190 200 210 220 230 240
RGWRSGAIVE KREIPMYYLR ITDYAEELLG DLDGLGWPER VKIMQQNWIG KSVGVRFAFK
250 260 270 280 290 300
HDIEGDDGQL INDGKLYVFT TRADTIMGVT FCAVAAEHPL ATHAAANNPE LAAFIDECKH
310 320 330 340 350 360
GSVMEADMAT MEKKGMPTGL QVTHPLTGEQ VDVWVGNYVL MSYGDGAVMG VPAHDERDFA
370 380 390 400 410 420
FANKYKLPIR QVIDVKGQPY STEAWQEWYG DKENGVCIES GKYNGLGYLA AVEAIAADLG
430 440 450 460 470 480
AMGLGEKKIT WRLRDWGISR QRYWGTPIPL IHCDSCGVVP VPEQDLPVVL PEDLVPDGTG
490 500 510 520 530 540
NPLNKDPRFL QCSCPSCGKP ARRETDTMDT FIDSCWYYMR YTCPDAATMV DARNDYWMPM
550 560 570 580 590 600
DQYIGGIEHA ILHLLYARFW TKVMRDLGLV KFDEPFTNLL TQGMVLNETF YREDAAGKKT
610 620 630 640 650 660
WYNPADVDVQ TDDRGRPVGA TLKADGQPVV IGGVEKMSKS KNNGIDPQAL IDQHGADTAR
670 680 690 700 710 720
LFVMFAAPPE QQLEWSGSGV EGASRFLRRV WNYGFANAAA VRDGAGAAPT ADDADLRREI
730 740 750 760 770 780
HGVLKQANYD YQRIQYNTVV SATMKMLNAL EDAKNASPVA RRECFGILLR VLYPVVPHIT
790 800 810 820 830 840
HGLWDALGYA TQYGDLLDAP WPQVDEGALV RTEIEMVLQI NGKVRGSVTV PADADRAAIE
850 860 870
TAAAASETVA KFAEGKAPKK IVVVPGRLVN VVL